Adult-Onset Satoyoshi Syndrome in a Young Male

Satoyoshi syndrome, a rare autoimmune condition, was reported in a 32-year-old Caucasian male in South America, marking the first adult onset case in the region. The patient experienced painful muscle spasms, trismus, and complete body hair loss starting at age 21. Diagnosis was confirmed through electroneuromyography and extensive investigation, with significant improvement seen using corticosteroids and azathioprine. This syndrome, typically seen in Asian children, has various atypical presentations, and immunosuppression remains the primary treatment approach. Awareness among neuromuscular disease professionals is crucial due to the potential positive response to treatment.