Treatment of Satoyoshi Syndrome: A Systematic Review

    June 2019 in “ Orphanet journal of rare diseases ”
    Julián Solís García del Pozo, Carlos de Cabo, Javier Solera
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    TLDR Corticosteroids are the most effective treatment for Satoyoshi syndrome.
    Satoyoshi syndrome, a rare multisystemic disease with presumed autoimmune origins, presented symptoms such as painful muscle spasms, diarrhea, alopecia, and skeletal abnormalities. A review of 64 cases from 1967 to 2018 revealed that muscle relaxants like dantrolene improved muscle symptoms in 13 out of 15 cases, while other muscle relaxants or anticonvulsants were less effective. Corticosteroids showed the best results, with 28 out of 30 cases responding positively. Immunosuppressive drugs were used to enhance corticosteroid efficacy or reduce dosage, and immunoglobulin therapy showed favorable responses in 4 out of 9 patients. Corticosteroids were the most effective treatment, but further studies were needed to optimize their use and explore the roles of other therapies.
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