Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that in a mouse model of Leigh syndrome, rapamycin alters brain proteome and may extend survival by targeting protein kinase C.

This source reports that clinical trials using advanced Deep Brain Stimulation systems, augmented with AI to integrate kinematic data, eye tracking, and cognitive assessments, show promise in improving diagnostic accuracy and monitoring symptoms for patients with Parkinson's disease.

Carbamazepine may cause reversible nail detachment.

In this study, DMC selectively eliminated senescent cells in old mice, prevented hair loss, improved motor coordination, and reduced senescence-associated secretory factors, suggesting its potential as a senolytic treatment.

This study indicated that administering letrozole to Swiss albino mice may have anticonvulsant effects against kainic acid-induced seizures by inhibiting testosterone aromatization to 17β-estradiol and increasing anticonvulsant metabolites in the hippocampus.

In this case report, a two-year-old girl with kerion type of tinea capitis successfully achieved clinical and mycologic cure with double pulse dose terbinafine and 2% ketoconazole shampoo over two months, with excellent tolerability and no side effects.

The authors concluded that capecitabine and high-dose toremifene may be an effective treatment option for patients unable to undergo anthracycline or taxane therapies, based on one woman's cancer management.

The researchers reviewed cepharanthine, a long-used bisbenzylisoquinoline alkaloid, for its antiviral properties, including significant inhibition of SARS-CoV-2. They discussed cepharanthine's other pharmacological actions, highlighted plasma membrane fluidity as a key antiviral mechanism, and examined its safety, bioavailability, and potential for new clinical applications.

In this study, a 14-year-old girl developed Malassezia folliculitis and seborrheic dermatitis after starting trametinib, which improved with itraconazole treatment. The research underscores the importance of recognizing trametinib-related skin reactions and suggests managing them with antifungal therapy without necessarily discontinuing the medication.

This source concludes that repurposing existing drugs, such as using metformin with other treatments in advanced non-small cell lung cancer, may enhance cancer patient outcomes, although various technical and legal challenges need addressing.

This review summarizes evidence and adverse event management recommendations for Sacituzumab Govitecan in metastatic triple-negative breast cancer and hormone receptor-positive breast cancer, emphasizing favorable survival data from clinical trials.

This study evaluated the real-world safety of Tepotinib for treating NSCLC with METex14 skipping mutations, confirming known adverse events and identifying new signals like deafness and taste disorder, especially highlighting early monitoring.

This review discusses the side effects of carbamazepine, valproate, and clonazepam, noting that these are rare with long-term use but more common, transient, and generally mild during early treatment.

In this study, Tolterodine Tartrate significantly improved symptoms of overactive bladder and showed fewer adverse reactions compared to the control group treatment.

This review examines the antitumor effects of metformin and highlights discrepancies between basic and clinical study results, noting that these may be due to different dosing levels.

In this study, Zusanli acupoint injections of metoclopramide significantly improved dyspeptic symptoms in patients with functional dyspepsia more than oral domperidone, with no adverse reactions in either group.

The combination of tretinoin, minoxidil, and betamethasone valerate may cause severe scalp inflammation.

Mitoxantrone with a corticosteroid helps manage symptoms for some advanced prostate cancer patients but doesn't extend life.

In this case report, a 54-year-old male experienced hair loss and discoloration after starting mirtazapine, with full hair regrowth and color restoration occurring within 10 weeks of stopping the medication.

This study observed that a combination of low-dose cyclophosphamide and vinorelbine appears safe and has promising antitumor activity in patients with metastatic breast cancer resistant to anthracyclines and taxanes, achieving a 44% objective response rate at 6 months with manageable toxicity levels.

Finasteride and bicalutamide can affect blood sugar, so diabetics need monitoring.

Finasteride and bicalutamide can affect blood sugar, so diabetics need monitoring.

In this study conducted at Shafa Hospital, Kerman, Iran, 3.5% of patients using sodium valproate as an antiepileptic experienced hair loss and curling over ten years.

In this study, leflunomide was effective in treating rheumatoid arthritis, showing comparable efficacy to methotrexate and greater response rates than sulfasalazine, but has significant side effects that require monitoring.

In this study, finasteride reduced the severity of dopaminergic behavior manifestations in rats without causing extrapyramidal side effects, unlike other antidopaminergic agents.

This study found that cepharanthine may be a promising treatment for enterovirus infections, as it offered full protection to mice against lethal EV71 challenges and reduced viral titers and pathology.