Canadian Expert Recommendations on Safety Overview and Toxicity Management Strategies for Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer

September 2024 in “ Current Oncology ”

Mita Manna, Michelle Brabant, Rowen Greene, M. Dean Chamberlain, Aalok Kumar, Nimira Alimohamed, Christine Brezden‐Masley

alopecia hormone receptor-positive breast cancer

TLDR Sacituzumab Govitecan is effective for certain breast cancers but requires careful management of side effects.

Sacituzumab Govitecan (SG) is an antibody-drug conjugate used in treating metastatic triple-negative breast cancer (TNBC) and hormone receptor-positive breast cancer. Recent Canadian funding has increased its use, leading to more experience in managing its adverse events (AEs). The review highlights evidence and recommendations from Canadian experiences, noting that SG is administered at 10 mg/kg on days 1 and 8 of a 21-day cycle. Phase III studies, ASCENT and TROPiCS-02, showed favorable survival outcomes compared to treatment of physicians' choice. Common AEs include neutropenia, diarrhea, nausea, fatigue, alopecia, and anemia. The review provides AE management strategies, including treatment delays, dose reductions, and the use of prophylactic and supportive medications, based on clinical trial protocols and Canadian guidelines.

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