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research EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair
This study found that abolishing H3K27me3 in mouse skin by targeting Ezh2 and Ezh1 affects hair follicle development and epidermal behavior, revealing functional differences between these tissues.
research Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity
This study found that the ablation of Esrp1 and Esrp2 disrupts epithelial tight junctions by affecting Arhgef11 isoform expressions, highlighting a potential mechanistic link between splicing alterations and epithelial barrier defects.
research Up-regulation of androgen receptor by heat shock protein 27 and miR-1 induces pathogenesis of androgenic alopecia.
This study investigates the role of AR up-regulation in the pathogenesis of androgenetic alopecia, but it remains unclear if HSP27 and miR-1 are jointly involved.
research Evaluating HWE and Association in Genome Wide Association Studies: A Unified Procedure
This study proposes a new test for genome-wide association studies that incorporates Hardy-Weinberg equilibrium into SNP analysis, demonstrating improved power and interpretability over traditional methods, as evidenced by simulations and an alopecia study dataset.
research A newly identified missense mutation of the HR gene is associated with a novel, unusual phenotype of Marie Unna Hereditary Hypotrichosis 1 including limb deformities
This study reports a novel missense mutation in the HR gene in a 68-year-old Hungarian woman with alopecia universalis and limb deformities, suggesting a need for further research on its role in these conditions.
research Identification and characterization of the hamster polyomavirus middle T antigen
In this study, researchers found that the ability of hamster polyomavirus to cause lymphoid tumors in Syrian hamsters may be linked to its association with the tyrosine kinase p59fyn.
research The HOXC13-controlled expression of early hair keratin genes in the human hair follicle does not involve TALE proteins MEIS and PREP as cofactors
research Hair-follicle associated pluripotent (HAP)-cell-sheet implantation enhanced wound healing in diabetic db/db mice
This study found that implanting hair-follicle-associated pluripotent stem cell sheets facilitated wound healing and early macrophage activity while reducing inflammation in a diabetic mouse model, suggesting clinical potential for difficult-to-heal diabetic ulcers.
research The Role of the Hairless (hr) Gene in the. Regulation of Hair Follicle Catagen Transformation
This study found that the loss of a functional hr gene in mice leads to premature and abnormal hair follicle regression, disrupting normal hair cycling and architecture.
research Roles of two sphingomyelin synthase isoforms in murine hair
This study found that knockout mice lacking SMS1 showed reduced body weight and hair loss, indicating a role for SMS1 in normal growth and hair health.
research Aminoacyl tRNA synthetase complex interacting multifunctional protein 1 induces proliferation of CD34+ hair follicle stem cell
This study found that the N-terminal fragment of AIMP1 enhances hair growth and proliferation of hair follicle stem cells in mice, suggesting its potential as a therapeutic peptide for hair loss treatment.
research Hispidulin ameliorates androgenetic alopecia by inhibiting dermal papilla cell ferroptosis via TRPML1 channel activation
research Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris)
This study identified genes potentially involved in the development and differentiation of skin appendages in Atelerix albiventris, noting significant enrichment of immune-related genes in hair-type tissues.
research Two Different Mutations in the Same Codon of a Type II Hair Keratin (hHb6) in Patients with Monilethrix
Mutations in the hHb6 gene cause the hair disorder monilethrix.
research Bone morphogenetic proteins 4 and 2/7 induce osteogenic differentiation of mouse skin derived fibroblast and dermal papilla cells
research DSP c.6310delA p.(Thr2104Glnfs*12) associates with arrhythmogenic cardiomyopathy, increased trabeculation, curly hair, and palmoplantar keratoderma
A specific gene variant is linked to heart disease, increased heart muscle, curly hair, and thick skin on palms and soles.
research The use of polyethylenimine–DNA to topically deliver hTERT to promote hair growth
This study found that transfecting hair follicle stem cells with a PEI-DNA complex expressing hTERT stimulated hair growth in rats by inducing follicle neogenesis and promoting the anagen phase.
research Human Hair Outer Root Sheath Cells and Platelet-Lysis Exosomes Promote Hair Inductivity of Dermal Papilla Cell
This study found that applying HHORSC exosomes may enhance the hair inductivity of dermal papilla cells, potentially improving treatments for hair loss.
research Hair follicle dermal stem cells and skin‐derived precursor cells: Exciting tools for endogenous and exogenous therapies
This review explores the role of hair follicle dermal stem cells in skin regeneration and restorative therapies, but it reports no new experimental results.
research 653 Substance P ameliorates epidermal thickness, basal cell density, and asymmetric stem cell self-renewal in skin with decreased sensory innervation
Substance P helps restore skin thickness and cell renewal when sensory nerves are reduced.
research A Study of Combined Genotype Effects of SHCBP1 on Wool Quality Traits in Chinese Merino
research TSH is a novel neuroendocrine regulator of selected keratins in the human hair follicle
TSH influences keratin expression in human hair follicles.
research 851 The role of astrotactin2 in regulating mammalian skin polarity
This study identified intramembrane proteolysis as a key feature of Astrotactin2 maturation, providing insights into its role in planar cell polarity hair patterning.
research Epidermal Dysplasia and Abnormal Hair Follicles in Transgenic Mice Overexpressing Homeobox Gene MSX-2
In this study, transgenic mice expressing Msx-2 developed flaky skin with hyperproliferation and misalignment in epidermal cells, suggesting Msx-2 plays a role in skin and appendage growth control.
research Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene
In this study, researchers found that overexpression of the hairless protein in Hr mutant mice disrupts inner root sheath formation by downregulating Dlx3 and associated keratins in hair follicle development.
research GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells
This study found that GLI2 plays a key role in activating follistatin, an activin/BMP antagonist, in response to hedgehog signaling in human epidermal cells, with implications for hair follicle development and basal cell carcinoma.
research 1392 Activation of Id2 gene regulatory network ruling quiescence of hair follicle stem cells
In this study using a transgenic mouse model, Id2 overexpression in hair follicle stem cells prolonged quiescence by affecting gene expression, partly independent from BMP signaling.
research Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease
This study created transgenic mouse models with the LMNA gene mutation common in Hutchinson-Gilford progeria syndrome, revealing skin and teeth abnormalities related to transgene expression levels.
research Understanding Sonic hedgehog (Shh) expression and its distribution in common house gecko (Hemidactylus platyurus) tail regeneration
This study found that Sonic hedgehog pathway expression strongly correlates with tail regeneration in house geckos, peaking early and decreasing afterward.