7 citations
,
March 2020 in “PloS one” This study demonstrates that α-parvin is crucial for epidermal morphogenesis and hair follicle development by mediating integrin-dependent adhesion and actin organization in keratinocytes.
This case report describes a transgender woman who achieved a soft, feminine hairline nine months post-hair transplant using follicles from both the occipital scalp and pubic area.
June 2019 in “Pediatric Dermatology” This review discusses the pathogenesis and clinical presentations of alopecia in epidermolysis bullosa patients, noting diverse hair abnormalities and emphasizing the lack of a consensus on its natural history.
55 citations
,
November 2004 in “Expert opinion on drug safety” This review describes the variety of mucocutaneous side effects caused by antineoplastic chemotherapy, with emphasis on skin, nails, and mucous membranes, while highlighting potential severity and the possibility of needing to adjust or interrupt treatment in rare cases; it presents no new clinical results.
32 citations
,
August 2003 in “Journal of the European Academy of Dermatology and Venereology” This article reviews the clinical aspects and potential mechanisms of chronic graft vs host disease skin manifestations, describing a novel form of premature skin aging, but presents no new research findings.
53 citations
,
November 1992 in “Mayo Clinic Proceedings” This review discusses the cutaneous manifestations associated with HIV infection, highlighting that these skin conditions often present atypically and are more severe compared to those in non-HIV-infected individuals; it reports no new clinical findings.
1 citations
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April 2022 in “Frontiers in Microbiology” In this study, amputees in Shanghai with amputation stump skin disease experienced severely reduced quality of life, with fungal infections and extended prosthetic wear identified as significant risk factors.
73 citations
,
June 2010 in “PLoS Genetics” This study identified that a deficiency in the palmitoyl transferase enzyme, due to a mutation in the Zdhhc13 gene, led to severe physiological abnormalities in mice, including skin, bone, and systemic amyloid issues.
1 citations
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October 2022 in “JCI insight” In this study, conditional deletion of BRD4 in OX40-expressing cells of mice led to alopecia, dermatitis, and loss of hair follicle stem cell function, revealing BRD4's role in skin inflammation and stem cell regulation.
5 citations
,
March 1943 in “Archives of Dermatology and Syphilology” This report describes a rare case of a woman with keratosis follicularis presenting with extensive alopecia and nail abnormalities, adding to the medical literature due to its unusual presentation.
June 2024 in “British Journal of Dermatology” In this prospective observational study of 96 dermatomyositis patients, 47 showed scalp involvement, with significant symptoms like scalp inflammation, itching, and hair loss linked to myositis-specific antibodies. The study highlighted unique dermatopathological features in the scalp and emphasized the considerable morbidity caused by scalp dermatomyositis.
8 citations
,
April 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified biallelic variants in the LSS gene as a possible genetic cause of palmoplantar keratoderma-congenital alopecia syndrome type 2, highlighting the role of cholesterol synthesis in skin cornification.
338 citations
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April 2001 in “Current Biology” This study found that transient activation of c-Myc in transgenic mice stimulates keratinocyte proliferation and sebocyte differentiation, affecting normal epidermal and hair follicle development.
37 citations
,
January 2010 in “Journal of Clinical Investigation” In this study, N-WASP deficiency in mouse skin was found to cause severe alopecia and disrupt hair follicle cycling by 5 months, highlighting its critical role in skin function and Wnt signaling.
21 citations
,
August 2017 in “Journal of veterinary internal medicine” The authors reported that a combination of amino acid and stem cell therapy may have extended survival in a dog with hepatocutaneous syndrome to 32 months post-diagnosis.
January 1982 in “Journal of The American Academy of Dermatology” Experts discussed treatments for skin conditions in children, emphasizing hydration, cautious medication use, and early intervention for infections.
October 2017 in “The American journal of gastroenterology” This case series highlights severe micronutrient deficiencies and complications in three patients who did not adhere to follow-up care after Roux-en-Y gastric bypass, emphasizing the importance of regular nutritional monitoring.
12 citations
,
March 2004 in “International Journal of Dermatology” A woman with X-linked chronic granulomatous disease developed lupus-like skin lesions, improved with treatment, suggesting a unique skin condition in carriers.
10 citations
,
July 2001 in “PubMed” This case report describes two patients with a likely new type of pachyonychia, characterized by nail thickening and severe generalized hypotrichosis, possibly linked to a mutation in a hard keratin.
4 citations
,
April 2024 in “Animals” This study reported allergic dermatitis in Brazilian donkeys linked to Culicoides insect bites, characterized by severe itching and skin lesions. The potential treatment with copaiba oil and multivitamin emulsion was explored, revealing its promise for managing this condition.
2 citations
,
May 2025 in “Journal of Clinical Medicine” This study reported that in a case series of three adolescents with alopecia areata and atopic dermatitis, treatment with 15 mg/day of upadacitinib led to rapid improvement in skin symptoms and significant hair regrowth over 12 months, with no severe adverse events observed.
May 2025 in “The Journal of Rheumatology” In this case report, researchers describe a rare instance of bullous lupus presenting with severe esophageal involvement in a 42-year-old woman, highlighting the significant diagnostic and therapeutic challenges encountered in such cases despite successful treatment with immunosuppressive therapy.
98 citations
,
December 2015 in “The Journal of Cell Biology” In this study, researchers found that the absence of type I or type II keratins in mice leads to severe skin barrier defects, highlighting keratins' crucial role in epidermal structure and function.
134 citations
,
September 2008 in “Lasers in surgery and medicine” This study found that low fluence photoepilation with intense pulsed light targets the pigmented area of hair follicles, causing temporary hair loss by inducing a catagen-like state without severe follicle damage.
65 citations
,
November 2013 in “The EMBO Journal” HDAC1 is crucial for skin development and preventing tumors.
July 2018 in “Journal of Dairy & Veterinary Sciences” In this veterinary case study, a 5-year-old Labrador with pruritus and alopecia tested positive for Malassezia pachydermatitis and recovered after treatment with oral terbinafine and topical ketoconazole.
5 citations
,
January 2016 in “Journal of The American Academy of Dermatology” This review discusses inflammatory and medication-related nephrocutaneous disease associations and emphasizes the importance of timely referral to nephrology for early management, but it reports no new clinical results.
38 citations
,
July 1998 in “Journal of surgical oncology” This review discusses acquired hypertrichosis lanuginosa, a rare disorder often linked to internal malignancy, and reports no new clinical findings; the authors highlight proposed pathogenic mechanisms for lanugo hair overgrowth.
28 citations
,
May 2000 in “Proceedings of the National Academy of Sciences” This study demonstrated that the highly divergent WDSV rv-cyclin significantly stimulates eukaryotic cell proliferation, leading to hyperplastic skin lesions in transgenic mice.
1 citations
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June 2022 in “Curēus” This case study highlights the unique occurrence of Papillon-Lefévre syndrome in two siblings from a consanguineous family, emphasizing the potential role of genetic factors in the disease's development.