Papillon-Lefèvre Syndrome: A Rare Case Report and a Brief Review of Literature

This case report discusses a rare instance of Papillon-Lefévre syndrome (PLS) in a 17-year-old Saudi boy from a consanguineous family, highlighting the genetic and immunological factors involved. The patient exhibited severe early-onset periodontitis, leading to the early loss of both primary and permanent teeth, and characteristic skin lesions with hyperkeratosis on the soles and erythematous patches on the palms. The report emphasizes the importance of early detection and multidisciplinary treatment for PLS patients, noting that the patient's elder brother, who also had PLS, was successfully treated.