Efficacy of Upadacitinib in Treating Alopecia Areata, Atopic Dermatitis, and Th1 Comorbidities in Pediatric Patients: A Comprehensive Case Series and Literature Review

    May 2025 in “ Journal of Clinical Medicine ”
    Chiara Battilotti, Giulia Azzella, Annunziata Dattola … Teresa Grieco
    Studysummary This study reported that in a case series of three adolescents with alopecia areata and atopic dermatitis, treatment with 15 mg/day of upadacitinib led to rapid improvement in skin symptoms and significant hair regrowth over 12 months, with no severe adverse events observed.
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    Research cited in this study 11

    1. Alopecia Areata: What's New in the Epidemiology, Comorbidities, and Pathogenesis? Journal of Dermatological Science · 2023
    2. Janus Kinase Inhibitors for Alopecia Areata: A Narrative Review Indian journal of dermatology, venereology, and leprology · 2023
    3. Upadacitinib for Successful Treatment of Alopecia Universalis in a Child: A Case Report and Literature Review Acta Dermato Venereologica · 2023
    4. Association of Atopic Dermatitis With Autoimmune Diseases: A Bidirectional and Multivariable Two-Sample Mendelian Randomization Study Frontiers in immunology · 2023
    5. Alopecia Universalis in an Adolescent Successfully Treated with Upadacitinib: A Case Report and Review of the Literature on the Use of JAK Inhibitors in Pediatric Alopecia Areata Dermatology and therapy · 2023
    6. Janus Kinase Inhibitors in the Treatment of Alopecia Areata Prague Medical Report · 2023
    7. Two Phase 3 Trials of Baricitinib for Alopecia Areata The New England Journal of Medicine · 2022
    8. Upadacitinib for the Treatment of Alopecia Areata and Severe Atopic Dermatitis in a Pediatric Patient: A Case Report SAGE open medical case reports · 2022
    9. The JAK/STAT Signaling Pathway: From Bench to Clinic Signal Transduction and Targeted Therapy · 2021
    10. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    11. Italian Guidelines in Diagnosis and Treatment of Alopecia Areata Giornale italiano di dermatologia e venereologia · 2019