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The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

Selective Androgen Receptor Modulators (SARMs) are drugs that can control the effects of androgens in different tissues, potentially having fewer side effects and promising for treating various conditions.

Transdermal testosterone can improve sexual desire in postmenopausal women but lacks long-term safety data and is not FDA-approved for this use.

Testosterone implants in women require pharmacological dosing to be effective and are generally safe and well-tolerated.

Flutamide combined with an LHRH agonist effectively inhibits prostate growth, suggesting it could treat prostate cancer.

A woman developed male traits from accidental contact with her husband's testosterone gel.

Androgens and SARMs play a role in body mass, frailty, skin health, and hair growth, and are used in treating prostate cancer, acne, and hair loss, with potential for new uses and improved versions in the future.

Most women referred for excess male hormone symptoms had polycystic ovary syndrome (PCOS), with other conditions being less common.

Finasteride effectively reduces hair growth in women with idiopathic hirsutism, but requires careful contraception during treatment.

Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.

Triptorelin helps evaluate hormone production in Sertoli-Leydig cell tumors.

Testosterone causes hair loss in AGA mice, which are good for testing baldness treatments, and both minoxidil and cyproterone acetate can prevent this hair loss.

Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.

Isoflavone may help manage PCOS symptoms, but its effectiveness is uncertain.

Low-dose gonadotropin treatment is effective for infertility in women with PCOS, leading to high ovulation rates and comparable pregnancy rates with fewer complications.

COVID-19 may harm male fertility and damage the reproductive system.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

Excess androgens may cause PCOS, not just be a symptom.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

Hormones like androgens, estrogen, thyroid hormones, and stress hormones can contribute to hair loss, and treatments target these hormonal imbalances.

Testosterone therapy for postmenopausal women appears safe and may protect against heart disease, but requires constant monitoring and more research for long-term effects.

Dutasteride, usually used for prostate issues and hair loss, could potentially treat Amyotrophic Lateral Sclerosis (ALS) due to its neuroprotective, antioxidant, and anti-inflammatory properties, but more testing is needed.

Experts agree that PCOS affects women's health in complex ways, but more research is needed to understand and treat it effectively.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Finasteride causes lasting fertility decrease in rats.

The conclusion is that a thorough approach is needed to diagnose and manage hyperandrogenism in teenage girls, recognizing its major psychological and health effects.

Diagnosing PCOS in teenage girls is tricky and requires careful evaluation and management.

Finasteride is effective and safe.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.