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CAP1/Prss8 does not activate PAR2 or inhibit PN-1.

Corin helps control salt and sweat release in sweat glands.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

Male hormones like testosterone may make COVID-19 worse, and testing for sensitivity to these hormones could help predict how severe a patient's symptoms might be. Treatments that reduce these hormones are being explored.

Human skin cells contain Protease Nexin-1, and male hormones can decrease its levels, potentially affecting hair growth.

People with PCOS have higher levels of PAI-1, which may increase their risk of heart disease and fertility issues.

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

SARS-CoV-2, the virus causing COVID-19, can affect all endocrine organs and systems, altering their function and potentially leading to disorders. Factors like diabetes and obesity increase infection risk and severity. Understanding these effects is key for effective treatment.

Sub3 is essential for fungus adherence but not for skin invasion.

Blocking enzymes that help the virus enter cells could be a promising way to treat COVID-19.

Sex hormones may affect COVID-19 severity, with men often faring worse, and targeting related pathways could offer treatment options.

The document highlights various patents for new compounds with potential treatments for multiple diseases, including cancer, hormonal disorders, and diabetes.

Wounds heal without scarring in early development but later result in scars, and studying Wnt signaling could help control scarring.

Early diagnosis and tailored treatments are crucial for managing ichthyosis syndromes with hair abnormalities.

The Megsin-Cre transgene is a new tool for genetic manipulation in the skin and upper digestive tract.

Netherton Syndrome can cause severe skin lesions in rare cases.

Certain mutations in the PADI3 gene may increase the risk of developing a type of scarring hair loss common in women of African descent.

The drugs finasteride and dutasteride reduce low-grade prostate cancers but may double the risk of high-grade cancers.

Terbinafine is more effective than itraconazole for toenail fungus, especially in older patients, and debridement improves its effectiveness.

Male pattern hair loss could hint at androgens affecting COVID-19 severity.

Men's sensitivity to male hormones might affect how severe COVID-19 gets for them.

Androgenetic alopecia linked to COVID-19 severity; drugs reducing androgen receptor activation may help.

Testosterone may have a dual role in COVID-19, potentially worsening outcomes in men, and testosterone therapy could help some patients, but more research is needed.

COVID-19 may affect male fertility and women might have better outcomes due to hormonal and immune differences.

A new mutation in the ST14 gene causes a rare skin and hair disorder in a specific family.

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

Fetal wounds heal without scarring because of different biological factors, which could help improve adult wound healing.

Minoxidil may help reduce aging effects in brain cells.

Managing metabolic syndrome needs both lifestyle changes and medical treatments.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.