2 citations
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May 2006 in “Women's Health Medicine” This article discusses polycystic ovary syndrome, describing its diagnostic criteria and noting that it is a common cause of anovulatory infertility and hirsutism, without reporting new research findings.
1 citations
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December 2025 in “World Journal of Biology Pharmacy and Health Sciences” This review highlights that pediatric hirsutism, often linked to endocrine, metabolic, genetic, or neoplastic disorders, requires comprehensive evaluation to prevent long-term health issues, integrating advancements in androgen biosynthesis understanding and diagnostic and management strategies.
1 citations
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November 2007 in “Humana Press eBooks” This article reviews the differential diagnosis and management approaches for androgen excess disorders, highlighting the predominance of polycystic ovary syndrome as the underlying cause and reports no new clinical findings.
1 citations
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January 2007 in “Humana Press eBooks” This review discusses the causes and treatments of hirsutism in women and reports no clinical results; it emphasizes the importance of identifying androgen-secreting tumors that require distinct therapy.
June 2026 in “Romanian Journal of Medical Practice” This case report describes a 72-year-old woman with a steroid cell tumor of the ovary, highlighting the critical role of imaging, biochemical evaluation, and pathology in diagnosing and managing hormonally active ovarian tumors that cause virilization in postmenopausal women.
May 2026 in “Annals of Internal Medicine Clinical Cases” This case report describes a postmenopausal woman with androgenic alopecia and progressive hirsutism who, despite normal imaging, had significantly elevated testosterone due to a Leydig cell tumor, revealed after surgical exploration; the condition improved post-surgery, underscoring the importance of considering such tumors in similar presentations.
January 2026 in “JCEM Case Reports” This case study describes two postmenopausal women with severe androgen excess symptoms, diagnosed with ovarian hyperthecosis and stromal hyperplasia, emphasizing the challenges in differentiating these benign conditions from androgen-secreting tumors and the importance of surgical and histopathological evaluation for correct diagnosis and management.
October 2025 in “Journal of the Endocrine Society” In this case report, the coexistence of hypercalcemia and androgen excess in a postmenopausal woman was linked to primary hyperparathyroidism and a suspected androgen-secreting ovarian tumor, underscoring the need for a comprehensive diagnostic approach to identify overlapping endocrine disorders.
May 2025 in “Journal of the ASEAN Federation of Endocrine Societies” This case report highlights the need to assess postmenopausal women with hirsutism for hyperandrogenism causes, as exemplified by a Leydig cell tumor coinciding with primary hyperparathyroidism.
May 2025 in “International Journal of Reproduction Contraception Obstetrics and Gynecology” In this case report, the researchers described a postmenopausal woman with androgenic symptoms who was found to have a benign Leydig cell tumor of the left ovary, indicated by elevated testosterone levels and MRI findings, which was successfully treated with surgery.
April 2025 in “The Journal of Clinical Endocrinology & Metabolism” This study highlights the global prevalence of hirsutism in women and reviews its diagnostic criteria, potential underlying causes like polycystic ovary syndrome, and treatment options, emphasizing the need for tailored, multifaceted management and acknowledging the distress it causes patients.
December 2024 in “AACE Clinical Case Reports” This study highlights a rare case of ovarian hyperthecosis in a 58-year-old postmenopausal woman, presenting with polycythemia and severe hyperandrogenism symptoms, with resolution of symptoms following laparoscopic bilateral oophorectomy.
March 2023 in “Bagcılar medical bulletin” This case report highlights a rare diagnosis of an androgen-secreting adrenal tumor in a patient with hyperandrogenism and virilization symptoms, emphasizing the role of gynecologists in early detection.
January 2023 in “Archives of Disease in Childhood Education & Practice” This article describes the causes of hirsutism, introduces a novel assessment tool, and suggests strategies for investigation and management, but provides no new experimental results.
Hyperandrogenism is diagnosed using clinical signs, lab tests, and imaging.
March 2021 in “Der Hautarzt” This review covers the clinical features, pathophysiology, differential diagnoses, and therapeutic options for neuroendocrine paraneoplastic syndromes affecting the skin but reports no new clinical findings.
January 2021 in “Voprosy ginekologii akušerstva i perinatologii” In this article, the authors detail approaches for diagnosing and managing hyperandrogenism in young women, focusing on conditions like polycystic ovary syndrome and hirsutism, and highlight the importance of differentiating physiological from pathological causes to guide appropriate treatment strategies, often involving combined oral contraceptives.
April 2020 in “Journal of the Endocrine Society” This case report details a post-menopausal woman with hirsutism and virilization due to rare Leydig cell tumors in both ovaries, underscoring the challenge of detecting such tumors with standard imaging.
This case report describes a 65-year-old postmenopausal woman with hyperandrogenism caused by a non-malignant ovarian Leydig cell tumor, which is a rare cause of virilization.
April 2019 in “Journal of the Endocrine Society” In this case report, a 48-year-old woman's hyperandrogenism, presenting with symptoms like acne and hirsutism, was attributed to a benign Leydig cell tumor, which resolved after surgical removal.
April 2019 in “Journal of the Endocrine Society” This case report highlighted rapid virilization in a woman with adrenocortical carcinoma, stressing the importance of androgen evaluation to suspect underlying ovarian or adrenal tumors.
June 2017 in “Acta Scientiae Veterinariae” This case report documents a cat with necrolytic migratory erythema due to glucagonoma and diabetes mellitus, highlighting similarities to glucagonoma syndrome in humans.
May 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study describes a postmenopausal woman's diagnosis with ovarian hyperthecosis, confirmed by a GnRHa test normalizing testosterone, highlighting hormone therapy as a therapeutic option when surgery is not feasible.
October 2020 in “Clinical and Experimental Dermatology” Hair loss improved after removing pituitary tumor.
140 citations
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April 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that mice lacking the 1αOHase enzyme, which is responsible for producing a key vitamin D metabolite, showed impaired epidermal differentiation and delayed recovery of skin barrier function after disruption.
96 citations
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October 1987 in “The Journal of Clinical Endocrinology & Metabolism” This study found that long-term GnRH agonist administration in premenopausal women with polycystic ovarian disease resulted in persistent suppression of ovarian steroid secretion, while adrenal steroid levels remained unchanged.
77 citations
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April 1968 in “Development” This study found that excess vitamin A in organotypic cultures of embryonic mouse skin led to abnormal hair follicle development and glandular metaplasia, unlike in untreated controls that showed normal differentiation.
76 citations
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May 2007 in “Menopause International” This review discusses the relationship between estrogen deficiency and skin aging in postmenopausal women, noting potential benefits of estrogen use on skin collagen and elasticity, but reports no new clinical results.
57 citations
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January 1995 in “The American journal of medicine” This study discusses the use of oral contraceptives as a treatment for hyperandrogenism, showing improvement in hirsutism and acne for many women and possibly providing metabolic benefits with certain formulations.
52 citations
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June 1999 in “Endocrinology and Metabolism Clinics of North America” This review concludes that antiandrogens with ovarian suppression may significantly improve hirsutism and androgenetic alopecia in women with PCOS, but treatment needs to continue unless the underlying PCOS cause is addressed.