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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

TRPA1 is crucial for mechanical sensitivity in skin sensory neurons.

New nanofiber technology improves wound healing by supporting cell growth and delivering treatments directly to the wound.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Erectile dysfunction is increasingly common in men under 40, with many physical and psychological causes, and various treatment options available.

Some medicinal plants can help heal wounds and may lead to new treatments.

Bioprinting could improve wound healing but needs more development to match real skin.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Gene therapy with the Math1 gene helped regenerate balance-related cells and improve balance in mice.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Stress increases nerve fibers and immune cell activity in mouse skin, possibly worsening skin conditions.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Pregnancy can increase lupus activity, but careful planning and treatment can improve outcomes.

A20 protein is crucial for normal skin and hair development.

Advanced human skin models improve drug development and could replace animal testing.

Ablative fractional resurfacing could improve how well topical drugs penetrate the skin, but more research is needed to fine-tune the method.

The research found that anovulatory young women have higher androgen and hormone levels than those who ovulate, suggesting immature hormonal regulation rather than a specific condition.

Small molecule drugs show promise for advancing regenerative medicine but still face development challenges.

Artesunate is generally safe for severe malaria, but patients should be monitored for delayed anemia after treatment.

Baby's toe injury linked to mom's hair loss; check baby's toes and be careful with fruit gel snacks.

Human platelets change minoxidil to minoxidil sulfate, helping blood vessels widen.

Bone-marrow and epidermal stem cells help heal wounds differently, with bone-marrow cells aiding in blood vessel formation and epidermal cells in hair growth.

Minoxidil improves blood flow and vessel flexibility, potentially helping with vascular stiffness.

The protein SLC1A3 is important for activating skin stem cells and is necessary for normal hair and skin growth in mice.

A natural steroid in the body may protect against eye damage in glaucoma.