November 2016 in “Oncology Letters” This study suggests that the expression patterns of keratin and filaggrin indicate milia may originate from the outermost cells of the hair bulge in the outer root sheath.
January 2016 in “프로그램북(구 초록집)” In this study, LED irradiation was found to promote hORSC proliferation and stimulate the Wnt5a/β-catenin and ERK signaling pathways, suggesting a potential mechanism for hair growth.
November 2012 in “International Journal of Data Science and Artificial Intelligence” This study found that the petroleum ether extract of Glycyrrhiza glabra roots promoted faster and longer hair growth in female Wistar rats compared to minoxidil and control treatments.
November 2008 in “Nursing” January 2008 in “Linchuang pifuke zazhi” This study found that betamethasone increased tyrosinase activity and melanin content in amelanotic melanocytes from human hair follicles, suggesting a potential mechanism for glucocorticoid treatment in vitiligo.
September 2004 in “Kitasato medical journal” This study found that a high dose of epidermal growth factor induced hair loss in sheep by causing apoptosis in anagen hair and transitioning the hair cycle to catagen.
January 1995 in “Skin Cancer” This review discusses the cell biological characteristics of the outer root sheath of normal human hair follicles and highlights some similarities and differences with trichilemmal tumors, but reports no new results.
131 citations
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January 2018 in “Scientific Reports” In this study, mycorrhizal fungal inoculation was associated with increased root-hair growth and enhanced drought tolerance in trifoliate orange by modulating auxin synthesis and transport under water stress conditions.
78 citations
,
May 2018 in “Plant Soil and Environment” This study found that inoculating tea plants with arbuscular mycorrhizal fungi significantly improved growth, root morphology, and leaf nutrient levels, with Claroideoglomus etunicatum showing the most substantial effects.
73 citations
,
June 2017 in “Experimental Dermatology” The authors suggest that tooth, dermal scale, epidermal scale, feather, and hair evolved in parallel from a shared placode/dermal cell unit in an early vertebrate gnathostome with odontodes, around 420 million years ago.
62 citations
,
February 2018 in “Scientia Horticulturae” In this study, the authors reported that mycorrhizal treatment in trifoliate orange seedlings affected root hair growth and auxin-related gene expressions differently under varying phosphorus levels.
61 citations
,
December 1994 in “Planta” 50 citations
,
March 2004 in “Trends in Plant Science” This paper discusses how NADPH oxidase and phospholipase D are important for root hair growth, with reactive oxygen species from NADPH oxidase activating calcium ion channels in root hairs.
46 citations
,
July 2015 in “Wound repair and regeneration” This study found that keloid tissues exhibit epithelial-mesenchymal transition-related changes and alterations in gene expression, implicating these processes in the pathogenesis of keloids.
43 citations
,
January 2016 in “Cellular physiology and biochemistry” This study reports that EGF at specific concentrations promotes the proliferation and migration of hair follicle ORS cells by activating the Wnt/β-catenin signaling pathway in vitro.
30 citations
,
October 2020 in “Frontiers in Plant Science” In this study, the combination of arsenic toxicity and hypoxia in Arabidopsis thaliana altered root development through stress-specific root growth phenotypes and changes in phosphate starvation response, energy metabolism, and redox signaling.
28 citations
,
July 2021 in “Pharmaceutics” This study found that Morus alba root extract activates β-catenin in hair follicle dermal papilla cells, promoting the transition to the anagen phase and enhancing hair growth factor secretion.
28 citations
,
December 2007 in “Proceedings of the National Academy of Sciences” This study observed that root hair growth in Arabidopsis occurs episodically, with each growth period associated with external alkalization and internal acidification, suggesting a role for proton influx in facilitating polar growth.
24 citations
,
May 2017 in “Annals of botany” This study found that root hair growth in Arabidopsis thaliana is stimulated by pathogenic Pseudomonas strains similarly to beneficial rhizobacteria, relying on ethylene signaling and an efficient exocyst-dependent secretory process.
17 citations
,
January 2009 in “Plant cell monographs” 16 citations
,
May 2020 in “Plant Growth Regulation” 15 citations
,
September 2018 in “Frontiers in Plant Science” This study identified that downregulation of the gene BcFLA1 decreases root hair length in Brassica carinata under phosphate-deficient conditions, highlighting its role in root hair elongation.
14 citations
,
April 2021 in “International journal of molecular sciences” This study found that human hematopoietic mesenchymal stem cells increased the viability and migration of human outer root sheath cells in an in vitro alopecia areata model, involving Wnt/β-catenin and JAK/STAT pathways.
13 citations
,
May 2023 in “Journal of Dermatological Science” This research found that reduced expression of SIRT1 in human scalp tissue may contribute to alopecia areata development by inducing immune-inflammatory responses in hair follicle cells, suggesting that SIRT1 plays a regulatory role in hair follicle immunity.
13 citations
,
February 2007 in “Biotechnology and Bioprocess Engineering”
12 citations
,
June 2019 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics” This study found that inhibiting the TRPV3 channel may significantly promote hair growth and suggests a potential therapeutic approach for hair loss and related skin diseases.
11 citations
,
May 2020 in “Frontiers in psychiatry” This study found that experiencing childhood abuse is associated with higher BMI, but hair cortisol and cortisone do not mediate this relationship.
10 citations
,
May 2006 in “Agricultural Sciences in China” This study found that a hydroponic buffer solution induced the formation of abundant long root hairs, termed "hedgehog roots," in several plant species but not in onions.
9 citations
,
August 2019 in “Journal of The European Academy of Dermatology and Venereology” Minoxidil activation by hair enzymes predicts treatment success for female hair loss.
9 citations
,
July 2008 in “Archives of Dermatological Research”