February 2024 in “Curēus” In this case report, secukinumab therapy for spondyloarthritis was associated with the development of alopecia areata in a 46-year-old woman, which improved after discontinuing the medication.
This case study observed that a patient with multiple refractory inflammatory conditions, including psoriasis, alopecia areata, and psoriatic arthritis, experienced significant improvements after three months of treatment with upadacitinib. The report suggests potential benefits of upadacitinib for similar conditions, recommending further clinical trials.
May 2023 in “American journal of clinical medicine research” This study assessed the quality of life of pediatric alopecia areata patients and their parents, finding that disease severity and child age significantly affect the child's quality of life, while the parents' emotional well-being is notably impacted.
This study found that while iron depletion through phlebotomies is safe for women with functional ovarian hyperandrogenism, it does not improve their cardio-metabolic profile and may reduce non-enzymatic antioxidant capacity.
January 2022 in “Nasza Dermatologia Online” In this study, dermoscopy was suggested as a potentially useful tool for improving the clinical recognition of pilomatricoma.
April 2021 in “Journal of Investigative Dermatology” This study observed that the proportion of female authorship, including lead authors, in top dermatology journals increased from 2018 to 2020, despite potential COVID-19 impacts, while female senior authorship rates still reflect gender disparity in senior positions.
June 2018 in “Disease-a-Month” This study observed that patients with burning mouth syndrome had higher levels of cystatin SN in resting saliva compared to healthy controls, suggesting a potential biomarker for the condition.
October 2017 in “The American journal of gastroenterology” This case series highlights severe micronutrient deficiencies and complications in three patients who did not adhere to follow-up care after Roux-en-Y gastric bypass, emphasizing the importance of regular nutritional monitoring.
October 2017 in “Journal of Investigative Dermatology Symposium Proceedings” This study suggests that PGD2 may increase testosterone production in keratinocytes through oxidative stress pathways, with n-acetyl-cysteine blocking this effect.
June 2017 in “Poster presentations” In this study, the safety profiles of four treatments for early rheumatoid arthritis were assessed over one year, and the most serious side effects necessitating treatment discontinuation were noted in the leflunomide group, whereas no such withdrawals occurred in the methotrexate plus prednisolone group.
June 2017 in “Journal of The American Academy of Dermatology” Women in Australia report different signs of facial aging compared to women in the US, UK, and Canada; men with Lichen planopilaris often have hormonal abnormalities and thyroid disease.
June 2017 in “Journal of The American Academy of Dermatology” Most men with lichen planopilaris had it confirmed by biopsy and often had thyroid issues, sexual dysfunction, or prostate cancer, hinting at a link with hormonal problems.
April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports that 71% of patients treated with the gamma-secretase inhibitor PF-03084014 for desmoid tumors experienced dermatologic side effects, such as follicular lesions and pruritic eruptions, which were managed with topical or systemic treatments.
January 2013 in “Yearbook of Urology” The Princeton III Consensus recommends assessing cardiovascular risk in men with erectile dysfunction and prioritizing heart health before treating ED, especially in those with potential heart disease.
January 2010 in “Actas Dermo-Sifiliográficas” A woman developed thick gums from everolimus treatment after a kidney transplant.
March 2008 in “Aging health” This research reported that docetaxel is generally safe and effective for elderly patients with solid tumor malignancies, showing no significant age-related differences in efficacy or toxicity.
February 2007 in “Facial Plastic Surgery” This review discusses the history and evolution of hair restoration surgery from the 1990s to today and reports no new clinical results.
This article reviews the synthesis and properties of isotretinoin, tazarotene, minoxidil, and finasteride, and reports no new findings.
October 1999 in “The Journal of Urology” This article discusses developments in clinical urology featured in the Journal of Urology's October 1999 issue and presents no new clinical findings.
This review discusses the link between selenium levels in the environment and related diseases in China, reporting no clinical results; the authors highlight the need for clearer geographic risk and remediation strategies.
April 2017 in “The Journal of Urology” This study found that patients with BPH who received finasteride before TURP experienced reduced intraoperative blood loss and improved quality of life one month after surgery compared to those who did not.
April 2021 in “Journal of Investigative Dermatology” This study found that transgender patients on masculinizing hormone therapy had a higher likelihood of developing acne compared to cisgender women, and were more likely to experience AGA compared to cisgender women.
June 2017 in “Journal of The American Academy of Dermatology” Microneedling with PRP and minoxidil (5%) improves hair growth more than minoxidil (5%) alone.
1707 citations
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December 2003 in “The New England Journal of Medicine” Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.
1265 citations
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October 2013 in “The Journal of Clinical Endocrinology and Metabolism” This guideline from the Endocrine Society recommends using the Rotterdam criteria for diagnosing polycystic ovary syndrome and outlines first-line treatments, emphasizing hormonal contraceptives and lifestyle intervention.
855 citations
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June 2009 in “The Journal of Clinical Endocrinology & Metabolism” The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.
418 citations
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September 2012 in “Nature” This study reports the first instance of skin autotomy in mammals, specifically in African spiny mice, and suggests they may possess a greater regenerative capacity than previously understood, possibly offering insights for regenerative medicine.
356 citations
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December 1986 in “The journal of cell biology/The Journal of cell biology” This study found that specific human hair keratins are differentially expressed in the hair follicle, suggesting a shared pathway of epithelial differentiation between hair cortex and nail plate cells.
260 citations
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July 2010 in “Cell” This study identifies mutations in the SRD5A3 gene as a cause of a new type of congenital disorder of glycosylation, impacting mental, ophthalmologic, and cerebellar functions.
242 citations
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January 2000 This study identified a strong association between heavy metal contamination in drinking water and chronic diseases like renal failure and liver cirrhosis in Great Cairo Cities, Egypt.