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The transcription factor Meis2 is essential for touch sensation and proper nerve development in touch receptors.

Dermal fibroblasts have adjustable roles in wound healing, with specific cells promoting regeneration or scar formation.

Blocking Janus kinase 1 helps stop inflammation and regrow hair, making it a good treatment for hair loss from alopecia areata.

The article concludes that creating a detailed map of normal human skin at the single-cell level is important.

Different small areas within hair follicles send specific signals that control what type of cells stem cells become.

New research shows that skin diversity is influenced by different types of dermal fibroblasts and their development, especially involving the Wnt/β-catenin pathway.

Versican, a protein, is less present in thinning hair follicles and this decrease might contribute to common hair loss in men.

Increasing Wnt5a in mice skin delays hair growth but doesn't stop it.

Twist2 is essential for scarless skin healing and hair growth in mouse fetuses.

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

TRPA1 is crucial for mechanical sensitivity in skin sensory neurons.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

The AUTS2 gene is linked to neurological disorders and may affect human brain development and cognition.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

Higher enzyme levels found in women with hair loss, suggesting hormone imbalance.

Inflammation plays a key role in activating skin stem cells for hair growth and wound healing, but more research is needed to understand how it directs cell behavior.

Low ERCC3 gene activity is linked to non-pigmented hair growth.

Stopping methotrexate might reverse lymphoma-like conditions in some patients.

Molecular diagnostics help identify genetic defects causing endocrine diseases, improving diagnosis and treatment options.

K6hf is a unique protein found only in a specific layer of hair follicles.

Fetal wound healing changes with development, affecting inflammation and collagen, which may influence scarring.

Growth factors are crucial for hair development and could help treat hair diseases.

Mouse skin can produce and process serotonin, with variations depending on hair cycle, body location, and mouse strain.

SHISA6 helps maintain certain stem cells in mouse testes by blocking signals that would otherwise cause them to differentiate.

Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.

Mice without the Sp6 gene have problems developing several body parts, including hair, teeth, limbs, and lungs.

Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.

Sp6 promotes tooth development by reducing follistatin levels.

The study found that variations in hair protein genes are likely due to evolutionary deletions or duplications.