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In this study, radiofrequency microporation significantly improved topical minoxidil delivery and hair regrowth in a mouse model of androgenetic alopecia, with minimal systemic exposure compared to oral administration, suggesting it could be a promising needle-free option for topical therapy.

This source discusses using stratum corneum ablation as a promising method to enhance transdermal drug delivery by temporarily removing the skin's outermost barrier to improve medication absorption.

This study compared the microscopic treatment zones created by different fractional lasers and radiofrequency in swine skin, finding distinct patterns and damage levels for each technology.

This review discusses the application of active transdermal technologies in cosmetic devices for skin restoration and enhancement, reporting no new clinical results.

In this study, the combination of ECM-C with microneedle and radiofrequency treatments improved periorbital wrinkles, skin elasticity, and thickness more effectively than ECM-C with microneedles alone, but subjective evaluations showed no significant differences.

This study found that radiofrequency microneedling significantly enhanced the absorption of topical triamcinolone acetonide, with insertion depth being more influential than RF energy levels.

This study reviews the evolution and modifications of microneedle drug delivery systems, initially designed for percutaneous use, now expanded for targeting a variety of tissues and organs such as ocular, oral mucosal, and gastrointestinal, suggesting widespread future applicability.

This review outlines the development, applications, and challenges of microneedle-based drug delivery from 2000-2019, particularly highlighting fabrication techniques, but reports no new clinical results.

This review explores the use of skin penetration enhancers like Transcutol® in various formulation systems, discussing their mechanisms and effectiveness in improving transdermal drug delivery without breaching the skin.

In this study, researchers established five new immortalized human dermal papilla cell lines from a male with androgenetic alopecia, which may serve as valuable tools for hair research.

This review highlights the promising potential of microemulsions and nanoemulsions in (trans)dermal drug delivery, noting a gap in understanding their distinct mechanisms and composition-related effects on skin permeability, while emphasizing the limited clarity on mesostructures and cosolvent impacts.

This systematic review examines the landscape of cosmetic microneedling using SWOT analysis, identifying strengths like precise delivery and self-administration, while noting challenges such as potential skin damage and regulatory issues, with opportunities in AI-enhanced targeted treatments noted by these researchers.

This review discusses various gene therapy and non-viral delivery methods to promote angiogenesis for chronic wound healing, but it reports no new clinical results.

This review summarizes recent progress in microneedle-based drug delivery systems and discusses their potential impact on cellular mechanisms and immunization signaling pathways, highlighting the need for further development in fabrication methods.

This review discusses transdermal drug delivery using hydrogel-forming microneedles and highlights their potential for disease treatment, but notes challenges in their clinical application.

This study found that fractional laser treatment significantly enhances the penetration and targeting of certain permeants, such as imiquimod and FD, to skin follicles, but not hydroquinone.

This article discusses the potential of novel microneedle transdermal systems for enhanced drug and vaccine delivery through the skin, but reports no clinical results and emphasizes ongoing trials.

This review highlights recent advances in personalized transdermal drug delivery systems, noting their potential for improved treatment efficacy and safety, but identifies significant challenges in clinical translation.

This review highlights the use of microneedling devices and patches to deliver cosmetic agents through the skin, noting their applications in skin rejuvenation and safety considerations such as potential skin irritation and infection.

This review highlights the promising potential of 3D printing for creating microneedles with precise customization and improved performance compared to traditional micromolding, emphasizing applications in personalized medical devices and advancements in biomedical fields.

This review discusses the advantages, applications, and current trends of dissolving microneedles for drug delivery across various therapeutic areas and reports no new clinical results.

This review discusses transdermal drug delivery using hydrogel-forming microneedles and highlights their potential and challenges for clinical application, but it reports no new clinical findings.

This study introduces a spherical skin model that effectively mimics key features of human skin, offering a scalable and rapid alternative for non-animal dermatological and cosmetic testing.

This review discusses emerging therapies for androgenetic alopecia, including topical finasteride, oral minoxidil, and intradermal dutasteride, and reports no clinical results; the authors highlight changes in treatment approaches.

In this ex vivo and in vitro study, researchers found that capacitive resistive electrical transfer therapy increased cell proliferation and reduced cell death in hair follicles from patients with androgenic alopecia, suggesting potential benefits for alopecia treatment.

RF-mesotherapy with bicalutamide may be a promising new treatment for hair loss.

Subcision is the most efficient, cost-effective, and safest treatment for post-acne boxcar scarring in skin of color.

This article discusses the historic use of oral minoxidil for severe hypertension and the subsequent development of a topical formulation for treating pattern hair loss, but reports no new results.

Scalp cooling reduces chemotherapy-induced hair loss without increasing risk of skin metastases.

This study found that ginsenoside Rf from Panax ginseng may serve as an effective anti-pigmentation agent by inhibiting the CREB/MITF pathway, reducing melanogenesis in melanocytes and UV-irradiated human skin.