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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

Isotretinoin improves severe acne without changing androgen or insulin levels but may increase body weight and triglycerides.

Hormonal therapies are safe and effective for treating adult women's acne.

Nonclassic congenital adrenal hyperplasia is a genetic disorder causing hormone imbalances, affecting fertility and requiring personalized treatment.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

Honokiol might help reduce male skin aging by maintaining testosterone levels.

Women with the NIH type of PCOS have more obesity and higher risk of diabetes and heart disease than those with other types of PCOS.

Certain genetic variants in the androgen receptor are linked to higher PSA levels, potentially affecting prostate cancer screening outcomes.

Menopause often leads to lower sexual desire and discomfort during sex, but treatment should be personalized and only if it bothers the woman.

Polycystic ovary syndrome (PCOS) was first described in 1721, officially diagnosed in the 1990s, and is now known to be partly genetic and linked to insulin resistance, with increased risk of cardiovascular disease and carbohydrate metabolism issues.

Hormone replacement therapy may lower the risk of severe COVID-19 outcomes in non-immunosuppressed people and male organ transplant recipients.

Adult acne is often related to hormonal disorders, especially in women, and may need long-term treatment involving specialists.

Ovarian Leydig cell tumors are hard to diagnose with just advanced imaging; expert ultrasound and clinical evaluation are essential.

Statins may help treat PCOS by lowering androgen levels and improving cholesterol.

Finasteride reduces hair growth better, but spironolactone has more side effects.

Testosterone replacement is recommended for men with low testosterone levels and symptoms of hypogonadism.

Testosterone therapy improves physical function, strength, and body composition in older men with low testosterone levels.

Gynecologists should provide comprehensive care for transgender patients, including mental health evaluation, hormone therapy, and surgical options, while monitoring for side effects and ensuring patient safety.

Hormonal imbalances during menopause may significantly contribute to Frontal Fibrosing Alopecia.

Ketoconazole reduced hair growth and improved acne in women, but caused side effects needing careful monitoring.

Genetic counselors should be culturally skilled and aware of transgender patients' unique health risks and needs.

The document concludes that understanding hair and feather regeneration can help develop new regenerative medicine strategies.

Polycystic Ovary Syndrome is linked to higher risk of hypertension and heart disease.

Healthcare providers need better education and resources to give competent and sensitive care to transgender patients.

PCOS is a complex condition that can lead to serious health issues, but early diagnosis and treatment can reduce these risks.

Dihydrotestosterone makes arteries stiffer in female mice by reducing estrogen receptor expression.

PCOS has many symptoms, with high androgen levels being the most common.

Postmenopausal hyperandrogenism, a condition with symptoms like increased hair growth and acne, is usually caused by PCOS but can also be due to other factors. It's diagnosed by checking testosterone levels and treated either by removing the adrenal tumor or through antiandrogen therapy.

Micronutrient supplements significantly improved PCOS symptoms in women.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.