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Metformin is safe in early pregnancy for women with PCOS and may reduce certain risks.

PCOS increases the risk of heart disease and type 2 diabetes in women.

The document concludes that managing skin conditions during pregnancy is important and requires specialized care.

Alopecia areata is a reversible, autoimmune-related hair loss that can have significant emotional impact and uncertain treatment effectiveness.

The document concludes that Syndromes of Severe Insulin Resistance are rare disorders with limited treatment options.

Certain skin drugs and topical agents, including some natural extracts and fragrances, can cause allergic reactions. Some hair dyes and extensions, as well as minoxidil, a hair growth treatment, can also cause allergies. Botulinum toxin A can effectively reduce sweat but may have temporary side effects.

After chemotherapy for a gestational trophoblastic tumor, normal pregnancy rates are possible, but there's a slightly higher risk of the tumor reoccurring in future pregnancies.

Postmenopausal ovary stromal cells have a unique makeup and limited steroid production, suggesting androgens come from the adrenal gland.

Primary care is key in managing PCOS, focusing on lifestyle changes and medications like birth control and metformin.

PCOS is a complex condition in women that can lead to health issues, and lifestyle changes are the best management approach.

Both metformin and pioglitazone improve PCOS symptoms, but pioglitazone is a good alternative for those who can't take metformin.

Dermatopathia pigmentosa reticularis causes skin discoloration, hair loss, and nail problems.

People with Epidermolysis bullosa have many health problems including poor oral health, which is often neglected due to other medical issues.

Mutations in the P2RY5 gene cause autosomal recessive woolly hair.

Acitretin is effective for severe skin conditions but has significant side effects and requires careful monitoring.

Bone marrow-derived stem cells improved healing and reduced scarring in second-degree burns in rats.

Calcium and magnesium in hair increase with age and are higher in adult women.

Genomic profiling for myeloid cancers can find important inherited mutations, but it's challenging when these mutations aren't related to the patient's symptoms.

Long COVID causes a wide range of long-lasting symptoms that change over time and are hard to diagnose and treat.

The document concludes that inflammation markers can be used in diabetes, vitamin D3 affects immune pathways, hyperthyroidism changes hormone levels, androgen levels help diagnose Adrenocortical Carcinoma, erectile dysfunction is linked to diabetes, hypogonadism is common in HIV-infected males, and hormones can be biomarkers for various conditions.

Most patients with chronic kidney disease had skin issues like paleness and dry skin, and treating these can improve their lives.

Targeted anticancer therapies can cause severe side effects similar to traditional chemotherapy, but with different types.

Vitamin D is important for bones, hair, blood pressure, and breast development.

Netherton's syndrome is linked to high IgE levels and unique skin and hair symptoms, and may improve with ammonium lactate lotion and allergy management.

Sostdc1 controls the size and number of hair and mammary gland structures.

Diabetes causes lasting cell dysfunctions, leading to serious complications even after blood sugar is controlled.

Keratin proteins are essential for keeping the cells in the human colon healthy and stable.

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

Disrupting β-catenin signaling in certain cells causes anorectal malformations.

The vitamin D receptor can work without its usual activating molecule.