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    Glossary RAF inhibitors

    block proteins involved in cell growth signaling pathways

    RAF inhibitors, also known as RAF kinase inhibitors, are a class of drugs designed to block the activity of RAF kinases, which are proteins involved in cell signaling pathways that control cell growth and division. These inhibitors are particularly important in the treatment of certain cancers, such as melanoma, where mutations in the RAF gene (e.g., BRAF mutations) lead to uncontrolled cell proliferation. By inhibiting RAF kinases, these drugs can help to slow down or stop the growth of cancer cells.

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    Research 30 of 364

    1. Abstract 1677: Epithelial hyperplasia induced by a selective B-Raf inhibitor, WYE-130600 Cancer Research · 2010 · 1 citations
    2. The incidence and management of cutaneous adverse events of the epidermal growth factor receptor inhibitors Postępy Dermatologii i Alergologii · 2017 · 18 citations
    3. Dermatologic Side Effects of Systemic Targeted Anticancer Therapy Springer eBooks · 2018
    4. Sorafenib-induced eruption resembling pityriasis rubra pilaris Journal of the American Academy of Dermatology · 2011 · 21 citations
    5. Cutaneous adverse effects of targeted therapies Journal of the American Academy of Dermatology · 2015 · 149 citations
    6. 329 Mechanisms of Cutaneous Adverse Events during Targeted Cancer Therapy 2022
    7. Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways Journal of Cellular Biochemistry · 2005 · 24 citations
    8. Self‐Assembled Peptide Hydrogels Loaded with Umbilical Cord‐Derived Mesenchymal Stem Cells Repairing Injured Endometrium and Restoring Fertility Advanced Healthcare Materials · 2024 · 11 citations
    9. Biological therapy in the treatment of melanoma Journal of Mind and Medical Sciences · 2018 · 3 citations
    10. From bench to babies – drug development for male subfertility Reproduction and Fertility · 2024
    11. The Cutaneous Side Effects of Selective BRAF Inhibitors and Anti-CTLA4 Agents: the Growing Role of the Dermatologist in the Management of Patients with Metastatic Melanoma Current Dermatology Reports · 2013 · 6 citations
    12. Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1 Frontiers in Cell and Developmental Biology · 2020 · 3 citations
    13. 696 MEK and BRAF inhibitors augment the production and accumulation of sebum in hamster sebocytes Journal of Investigative Dermatology · 2016
    14. BRAF Inhibitor Dabrafenib in Patients with Metastatic <i>BRAF</i>-Mutant Thyroid Cancer Thyroid · 2014 · 188 citations
    15. Molecular targeted therapies for cancer: Sorafenib mono�therapy and its combination with other therapies (Review) Oncology Reports · 2012 · 46 citations
    16. Management of Toxicities of Targeted Therapies Elsevier eBooks · 2018 · 2 citations
    17. Cutaneous adverse effects of BRAF inhibitors in metastatic malignant melanoma, a prospective study in 20 patients. Journal of the European Academy of Dermatology and Venereology · 2014 · 31 citations
    18. Cutaneous reactions to chemotherapeutic drugs and targeted therapy for cancer Journal of the American Academy of Dermatology · 2014 · 88 citations
    19. Clinical management of cutaneous adverse events in patients on targeted anticancer therapies and immunotherapies: a national consensus statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology Clinical & Translational Oncology · 2018 · 26 citations
    20. Wound healing with topical BRAF inhibitor therapy in a diabetic model suggests tissue regenerative effects PLOS ONE · 2021 · 3 citations
    21. 801 TEC family kinase inhibitors as a novel class of therapeutics in alopecia areata Journal of Investigative Dermatology · 2024
    22. B-Raf and C-Raf Are Required for Melanocyte Stem Cell Self-Maintenance Cell Reports · 2012 · 26 citations
    23. New small molecules in dermatology: for the autoimmunity, inflammation and beyond Inflammation Research · 2023 · 9 citations
    24. Dermatologic adverse events associated with chemotherapy and targeted anticancer therapy Dermatology Review · 2016 · 4 citations
    25. Sorafenib-induced Facial Acneiform Eruption Cureus · 2019
    26. Keratosis Pilaris-like Eruption during Treatment of Chronic Myeloid Leukemia with Tyrosine Kinase Inhibitors: Literature Review and Report of a Case Related to Imatinib Journal of clinical medicine · 2023
    27. First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors Journal of clinical oncology · 2011 · 505 citations
    28. The PDGF/PDGFR pathway as a drug target Molecular Aspects of Medicine · 2017 · 182 citations
    29. Protein-phosphatase inhibitors block root hair growth and alter cortical cell shape of Arabidopsis roots Planta · 1994 · 61 citations
    30. Perspectives in dermatopathology: telomeres and telomerase in ageing and cancer; with emphasis on cutaneous disease Journal of Cutaneous Pathology · 2000 · 11 citations