85 citations,
June 2015 in “Scientific Reports” The study found that diseases can be grouped by symptoms and that the accuracy of predicting disease-related genes varies with the data source.
82 citations,
August 2006 in “Pharmacology, Biochemistry and Behavior” Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.
56 citations,
January 2019 in “Skin appendage disorders” The most common hair loss type at specialist clinics is androgenetic alopecia, especially in younger men, followed by alopecia areata and telogen effluvium, with differences seen across regions.
44 citations,
July 2011 in “Dermato-endocrinology” Thyroid hormone affects skin health, with too little causing rough, pale skin and too much leading to smooth, thin skin, and may also impact wound healing and skin conditions.
44 citations,
May 2006 in “The Journal of the American Animal Hospital Association/Journal of the American Animal Hospital Association” Both treatments for pemphigus foliaceus in dogs are effective, but combination therapy has more side effects.
41 citations,
August 1988 in “Journal of The American Academy of Dermatology” A woman with subacute cutaneous lupus erythematosus had widespread skin symptoms triggered by medication and sunlight, which improved with specific treatments.
40 citations,
December 2012 in “Epilepsia” Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.
39 citations,
March 2008 in “Journal of biological chemistry/The Journal of biological chemistry” GLI2 increases follistatin production in human skin cells.
37 citations,
January 2004 in “Hormone Research in Paediatrics” About 3% of high school girls aged 14-18 in Isfahan, Iran, have polycystic ovary syndrome.
34 citations,
November 2011 in “Alcoholism: Clinical and Experimental Research” Three drugs change mice's alcohol drinking patterns by affecting GABAA receptors.
32 citations,
May 2010 in “Pharmacopsychiatry” Finasteride reduces new brain cells in male mice, possibly causing depression.
31 citations,
November 2014 in “Investigative Ophthalmology & Visual Science” A natural steroid in the body may protect against eye damage in glaucoma.
30 citations,
February 2017 in “Histochemistry and Cell Biology” TPA promotes hair growth by increasing stem cell activity and activating specific cell signals.
30 citations,
February 2003 in “Annals of Neurology” Progesterone and related compounds may help control seizures linked to the menstrual cycle but have limitations that need addressing.
24 citations,
July 2011 in “PubMed” Thyroid hormones affect skin texture, hair and nail growth, and can cause skin diseases related to thyroid problems.
23 citations,
July 2003 in “Pharmacology, Biochemistry and Behavior” Finasteride blocks progesterone's effect on absence seizures in rats.
22 citations,
October 2019 in “Cerebral cortex” Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.
21 citations,
December 2016 in “PLOS ONE” Scientists made skin stem cells from other human cells with over 97% efficiency, which could help treat skin conditions.
21 citations,
April 2011 in “Epilepsia” The drug combination significantly reduced epileptic drop attacks in patients.
21 citations,
January 1995 in “Journal of the American Institute for Conservation” A new method extracts red dyes from wool without damaging it, although it slightly weakens the wool.
20 citations,
November 2019 in “Stem Cells” Hes1 protein is important for hair growth and regeneration, and could be a potential treatment for hair loss.
19 citations,
April 2016 in “Experimental Dermatology” Melanoblasts migrate to the skin using various pathways, and understanding this process could help with skin disease research.
19 citations,
April 2015 in “Stem Cells” Pro-IGF-II improves muscle repair in old mice.
19 citations,
November 1993 in “Mammalian Genome” A gene mutation in mice causes permanent hair loss and skin issues.
16 citations,
December 2006 in “International Journal of Dermatology” A woman died from cancer that spread from a long-standing cyst on her abdomen.
16 citations,
July 1996 in “Dermatologic Clinics” Some psychiatric drugs can cause skin problems, but serious reactions are rare.
13 citations,
December 2017 in “CNS Neuroscience & Therapeutics” Finasteride affects young male rats' brain function and behavior negatively.
13 citations,
January 1995 in “Journal of the American Institute for Conservation” Researchers developed a less damaging way to extract red dyes from wool using EDTA and DMF, preserving the fiber's strength for further analysis.
12 citations,
October 1996 in “Dermatologic Clinics” A simplified method was introduced to diagnose most hair loss types by examining the patient's history and scalp, with some cases needing further tests.
10 citations,
December 2017 in “Chemosphere” Bisphenol-A (BPA) increases connections between brain cells and boosts their activity, but it blocks the effects of a male hormone on brain cell plasticity.