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Anti-androgens are effective for female acne but less so for male-pattern hair loss, with side effects similar to birth control pills.

Male androgenetic alopecia involves hair follicle miniaturization due to DHT, with potential treatments using inhibitors and blockers.

New liposome treatment successfully delivers CRISPR to deactivate a key enzyme in androgen-related disorders.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

The document is a detailed medical reference on skin and genetic disorders.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

The conclusion is that tritium-labeled testosterone metabolites can be made and are better converted into dihydrotestosterone in skin cells than in prostate tissue.

Bald men are not more virile and may have fewer sexual partners.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.

Finasteride may treat baldness but less effective for those with 5α-reductase deficiency.

The enzyme that changes testosterone to a stronger form is mostly found in the part of the hair follicle called the dermal papilla.

Steroidogenic isoenzymes may help improve treatments for common hair loss.

Male pattern baldness involves hormone-related hair thinning, shorter hair, and inflammation.

AGA in children needs careful diagnosis due to low androgen levels and possible other causes.

New oral treatment, finasteride, effectively and safely treats common hair loss.

The document concludes that androgenetic alopecia is common, has a genetic link, and can be diagnosed and treated with medications like finasteride and minoxidil.

A new gene mutation causes female pseudohermaphroditism due to glucocorticoid resistance.

Individuals with male pseudohermaphroditism often do better raised as females with early surgery.

Five new mutations in the androgen receptor gene were found, helping to understand androgen insensitivity syndrome better.

The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.

The human type II 5α-reductase gene has a specific structure important for understanding certain medical conditions.

Dihydrotestosterone (DHT) is crucial for conditions like male-pattern baldness and acne, and measuring a byproduct, androstanediol glucuronide, is a better way to assess DHT's effects than DHT blood levels.

A Saudi individual initially identified as a girl had a genetic disorder affecting gender development.

The exact cause of increased 5α-reductase activity leading to hirsutism in women is still unknown.

A woman had both Graham Little-Piccardi-Lassueur syndrome, causing hair loss, and complete androgen insensitivity syndrome, making her genetically male but physically female. This suggests androgens don't affect the hair loss condition.

The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.

Curcumin and its derivatives can block an enzyme important for making testosterone, with one derivative being particularly strong.

Finasteride shows promise for treating hair loss and excessive hair growth, but more research is needed to confirm its effectiveness and safety.