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    Glossary Prostaglandin D2 Receptor

    protein on cell surfaces that binds prostaglandin D2, affecting hair growth

    The Prostaglandin D2 Receptor (often abbreviated as PTGDR or PTGDR2) is a protein found on the surface of certain cells that binds to prostaglandin D2, a type of lipid compound involved in various physiological processes. This receptor plays a significant role in inflammatory responses and has been linked to conditions like asthma and hair loss, particularly androgenetic alopecia, where its activation can inhibit hair growth.

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    1. Prostaglandin D2(PGD2); prostaglandin D2 receptor (CRTH2; GPR44; CD294); prostaglandin D2 synthase (PTGDS) Science-business Exchange · 2012 · 2 citations
    2. Expression Level of Prostaglandin D2 Receptor 2 Regulates Hair Regression Journal of Investigative Dermatology · 2019 · 2 citations
    3. Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells International Journal of Molecular Sciences · 2018 · 18 citations
    4. Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis through the Receptor, Gpr44 Journal of Investigative Dermatology · 2012 · 68 citations
    5. 15-deoxy prostaglandin J2, the nonenzymatic metabolite of prostaglandin D2, induces apoptosis in keratinocytes of human hair follicles: a possible explanation for prostaglandin D2-mediated inhibition of hair growth Naunyn-Schmiedeberg's Archives of Pharmacology · 2016 · 11 citations
    6. Faculty Opinions recommendation of Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2012
    7. The physiological and pharmacological roles of prostaglandins in hair growth The Korean Journal of Physiology and Pharmacology · 2022
    8. Role of prostaglandins in androgenetic alopecia Prostaglandins & Other Lipid Mediators · 2026
    9. 699 Effect of Prostaglandin D 2 on hair follicle growth and its impact on hair follicle stem/progenitor cells Journal of Investigative Dermatology · 2016 · 1 citations
    10. Faculty Opinions recommendation of Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2016
    11. Faculty Opinions recommendation of Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2012
    12. New drugs under investigation for the treatment of alopecias Expert Opinion on Investigational Drugs · 2019 · 26 citations
    13. Hair Growth-Promoting Effects of a Multi-Targeted Cosmetic Formulation Containing PYGL, DP2, and 15-PGDH Inhibitors Developed Using AI-Based DeepZema® in Androgenetic Alopecia: A 24-Week Randomized Controlled Trial Cosmetics · 2026
    14. Cicatricial Alopecia Symposium 2011: Lipids, Inflammation and Stem Cells Journal of Investigative Dermatology · 2012 · 4 citations
    15. Genetic and molecular aspects of androgenetic alopecia Indian Journal of Dermatology, Venereology and Leprology · 2018 · 24 citations
    16. 702 dsRNA induces ectopic KRT9 expression via WNT/β-catenin-mediated signaling Journal of Investigative Dermatology · 2016
    17. Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice—A Mechanistic Systematic Review International Journal of Molecular Sciences · 2022 · 10 citations
    18. Go with the Flow Scientific American · 2012
    19. A new target for squamous cell skin cancer? Experimental Dermatology · 2014 · 6 citations
    20. Hot Stuff: Thermal Imaging Aids in Cellulitis Diagnosis Journal of Investigative Dermatology · 2018 · 4 citations
    21. 701 Signaling networks between stem cell precursors, transit amplifying progenitors, and their niche in developing hair follicles Journal of Investigative Dermatology · 2016
    22. 男性型脱毛症の原因についての手がかり Nature digest · 2012
    23. Тіе Modern treatment of androgenetic alopecia Vestnik dermatologii i venerologii · 2017
    24. The therapeutic potential of CRTH2/DP2 beyond allergy and asthma Prostaglandins & Other Lipid Mediators · 2017 · 24 citations
    25. News updates Lab Animal · 2012
    26. Does prostaglandin D<sub>2</sub> hold the cure to male pattern baldness? Experimental Dermatology · 2014 · 57 citations
    27. It's Not “Like Growing Grass” Scientific American · 2012
    28. Does Inhibition of Aldose Reductase Contribute to the Anti-Inflammatory Action of Setipiprant? Physiological Research · 2017 · 6 citations
    29. In silico prediction of prostaglandin D2 synthase inhibitors from herbal constituents for the treatment of hair loss Journal of Ethnopharmacology · 2015 · 30 citations
    30. Divergent proliferation patterns of distinct human hair follicle epithelial progenitor niches in situ and their differential responsiveness to prostaglandin D2 Scientific Reports · 2017 · 21 citations