January 2023 in “International Journal of Trichology” This study found that bicalutamide mesotherapy resulted in subtle hair density improvements and was well tolerated by premenopausal women with androgenetic alopecia.
21 citations
,
January 2008 in “Journal of Pediatric Endocrinology and Metabolism” This study found that combined treatment with anastrozole and cyproterone acetate improved the adult height prognosis in testotoxicosis, as observed in two brothers, with good tolerance reported.
29 citations
,
October 2009 in “Pharmacology Biochemistry and Behavior”
5 citations
,
July 2021 in “medRxiv (Cold Spring Harbor Laboratory)” This study found that proxalutamide improved immunologic, inflammatory, thrombotic, and oxygen markers in both female and male COVID-19 outpatients, which may support its association with lower hospitalization rates compared to standard care.
1 citations
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November 2016 in “Frontiers in neurology” In this case report, a patient with Cronkhite-Canada syndrome also had mononeuritis multiplex, and the authors suggest that an autoimmune mechanism may be involved based on steroid responsiveness and electrophysiological findings.
35 citations
,
August 2001 in “Journal of Cutaneous Medicine and Surgery” This paper reviews the use of tacrolimus for various conditions, noting its effectiveness in treating certain skin disorders but highlighting that some findings remain anecdotal due to limited case numbers.
19 citations
,
October 2018 in “Medicine” In this meta-analysis, researchers found that moxibustion combined with oriental herbal medicine may improve pregnancy rates and other outcomes in women with polycystic ovary syndrome compared to western medication alone; however, the evidence is limited by the poor quality of included studies.
March 2005 in “Journal of The American Academy of Dermatology” Mycophenolate mofetil improved skin condition in a man with nephrogenic fibrosing dermopathy.
September 2023 in “Journal of the American Academy of Dermatology” Methylprednisolone treatment helps most alopecia areata patients, but young age, extensive hair loss, and low vitamin D can affect results.
April 2023 in “Journal of Investigative Dermatology” This study suggests that the CsA-induced inactivation of the CaN/NFAT pathway may suppress TGF-β2 expression in dermal papilla cells, potentially contributing to CsA-associated hypertrichosis.
May 2024 in “Brain disorders” In this animal study, agmatine exhibited a protective effect against seizures related to hormone fluctuations, with results suggesting that its anticonvulsant properties may involve interactions with central neurosteroids in female rats experiencing progesterone withdrawal.
April 2021 in “Research Square (Research Square)” This study found that the new cocrystal formulation KET-PABA improved the antimycotic efficiency of ketoconazole and induced an anti-inflammatory response without causing skin sensitization in mice.
In this study, metformin, pioglitazone, and ethinylestradiol cyproterone all improved various clinical features and quality of life in Pakistani women with PCOS, though no drug significantly reduced hirsutism.
42 citations
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January 1998 in “BioDrugs” Azathioprine's effectiveness and safety require careful monitoring and more research, especially regarding its use with corticosteroids and the role of TPMT status in patients.
26 citations
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December 1981 in “British journal of dermatology/British journal of dermatology, Supplement” This study observed that most hirsute patients on combined cyproterone acetate and 'Diane' therapy experienced a reduction in hair growth, with hair becoming softer, thinner, and lighter in color over 12 months.
2 citations
,
October 2024 in “JCEM Case Reports” This study describes a case of a 35-year-old woman who developed symptoms of hyperandrogenism and disrupted steroidogenesis due to chronic use of electronic cigarettes containing compounds similar to etomidate, despite no genetic mutation indicating 11β-hydroxylase deficiency.
15 citations
,
November 1997 in “Australasian Journal of Dermatology” This report describes a case where a patient with acute generalized pustular psoriasis achieved remission using a combination of oral cyclosporin and PUVA therapy, maintaining remission 12 months after stopping treatment.
This study found that cyproterone compound is not more effective than oral isotretinoin in treating nodulocystic acne in adult females with SAHA syndrome or cutaneous hyperandrogenism, suggesting isotretinoin may be preferable due to its established effectiveness in reducing acne lesions.
21 citations
,
February 2021 in “BMJ case reports” This case study potentially links the use of anabolic steroids to increased severity of COVID-19 in a healthy 28-year-old man, with marked symptom improvement following treatment with proxalutamide.
February 2023 in “Reactions Weekly”
May 2015 in “Journal of The American Academy of Dermatology” This study presents an algorithm that may help physicians diagnose female hair loss by synthesizing patient history, clinical examination, and various diagnostic tests.
25 citations
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December 2017 in “The Journal of Clinical Endocrinology & Metabolism” This study found that using an oral contraceptive with bicalutamide significantly reduced hirsutism in women with PCOS compared to an oral contraceptive alone, although it increased total cholesterol and LDL levels.
44 citations
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April 2019 in “Journal of the American Academy of Dermatology” This study observed that cyclosporine showed a trend toward improving alopecia areata symptoms compared to placebo, but the difference was not statistically significant.
January 2001 in “대한피부과학회지” This study reports that oral minipulse therapy with betamethasone was effective in promoting hair regrowth and managing alopecia areata with fewer side effects than traditional pulse therapies.
August 1993 in “Journal of dermatological science”
9 citations
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February 2013 in “Hormone and Metabolic Research” This study reported that CYP21A2 heterozygous mutations do not significantly contribute to the pathogenesis of polycystic ovary syndrome.
10 citations
,
August 1990 in “Journal of Steroid Biochemistry” High doses of cyclosporine A increase testosterone conversion, possibly boosting hair growth.
39 citations
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October 2012 in “Headache The Journal of Head and Face Pain” This study reports cutaneous atrophy and alopecia in four patients following greater occipital nerve blockade with triamcinolone and lidocaine, suggesting that alternative steroids may reduce these side effects.
September 2002 in “Fertility and sterility” This study found that metformin therapy is associated with the initiation of ovulatory cycles in women with PCOS and a trend toward reduced 17P responses after six months, but did not improve hirsutism or body composition.
42 citations
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July 2021 in “Frontiers in Medicine” In this study, proxalutamide significantly reduced the 30-day hospitalization rate by 91% compared to placebo in men with COVID-19 treated in outpatient settings.