January 2022 in “Physics and Chemistry of Liquids” This study investigated the solubility of minoxidil in various solvent mixtures and applied multiple models to understand solute-solvent interactions and energy dynamics.
38 citations
,
July 2019 in “Nature Communications” This study found that Par3 plays a crucial role in maintaining epidermal homeostasis by regulating Rho/actomyosin contractility and ensuring mitotic accuracy, with potential implications for other self-renewing epithelia.
34 citations
,
January 2014 in “International Journal of Trichology” This study reported that polarized dermoscopy was better for visualizing vascular patterns, scaling, and reticular pigmentation, while nonpolarized mode better documented features like black dots and tapered hair in various hair and scalp conditions.
31 citations
,
June 2022 in “Scientific Reports” This study presents a method using polarization-sensitive optical coherence tomography to accurately assess the depth of burn wound damage in the dermal collagen matrix, potentially improving diagnosis beyond traditional visual methods.
28 citations
,
September 1986 in “Pediatric dermatology” In this study, hair anomalies associated with acrodermatitis enteropathica in a young girl improved significantly after two years of zinc therapy.
26 citations
,
July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, loss of epidermal Par3 in mice disrupted the skin barrier and affected cell differentiation and stem cell maintenance, highlighting its role in epidermal homeostasis.
18 citations
,
May 2013 in “Journal of The American Academy of Dermatology” This study concludes that elastic tissue staining is the most reliable method for identifying scarring patterns in alopecia biopsy specimens, and polarized microscopy may provide specific insights for nonscarring alopecia.
15 citations
,
August 1991 in “American Journal of Medical Genetics” This study observed that a low-protein, arginine-supplemented diet improved the abnormal hair appearance in untreated patients with argininosuccinic aciduria.
13 citations
,
September 2011 in “Archives of dermatology” This case report describes a 3-year-old male with X-linked ichthyosis and associated neurologic abnormalities, identifying an unusual cortical development malformation and suggesting that abnormal hair banding may assist diagnosis.
11 citations
,
January 2012 in “Archives of Dermatology” Polarized microscopy is a quick and free method to correctly identify types of hair loss.
5 citations
,
May 2021 in “EMBO journal” This review discusses the role of polarity signaling in coordinating tissue mechanics, micro-environmental functions, and cell fate decisions, but it reports no new results, highlighting the need for further study in mammalian models.
5 citations
,
September 2005 in “Dermatologic Surgery” This study reports that using LED polarized magnification in hair transplant recipient sites can reduce eye strain and improve ease of site creation, but offers no graft placement advantage over traditional methods.
2 citations
,
February 2025 in “Dermatology and Therapy” In this observational retrospective study, UVF-dermoscopy was found to be more effective than polarized dermoscopy in identifying follicular features and distinguishing between scarring and nonscarring alopecias, particularly in individuals with lighter skin tones.
1 citations
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March 2006 in “Dermatologic Surgery” This study found that using polarized magnification during hair transplant procedures may ease recipient site creation and reduce transection of existing hair follicles, potentially maximizing hair density.
June 2026 in “Journal of Cutaneous Pathology” This study found that polarized light microscopy is more effective than diffractive microscopy in distinguishing scarring from non-scarring alopecia, providing a highly specific adjunct diagnostic tool for alopecia biopsy specimens.
This study utilized polarized light microscopy to examine hair shafts in ten children with rare genetic disorders, such as Netherton syndrome and ectodermal dysplasia, providing valuable diagnostic insights into hair thickness, composition, and structural irregularities associated with these conditions.
May 2024 in “International Journal of Cosmetic Science” This study found that using near-infrared optics, specifically in the second NIR window, allows for effective noninvasive evaluation of intra-hair damage caused by cosmetic treatments, demonstrating distinct damage types and changes in hair condition due to chemical or thermal processes.
March 2024 in “INDIAN JOURNAL OF APPLIED RESEARCH” In this case report, the authors describe using Polarity Analysis for selecting homeopathic remedies to better match patient symptoms in treating alopecia areata, offering a potential alternative to corticosteroids, which are associated with significant side effects.
September 2018 in “The Medical Journal of Cairo University/The Medical Journal of Cairo University” In this study, polarized light therapy increased hair regrowth in patients with alopecia areata compared to those who received only minoxidil.
September 2016 in “Journal of Dermatological Science” Polarizing light microscopy can easily and reliably diagnose congenital keratinizing disorders like Netherton syndrome.
3 citations
,
June 2025 in “Journal of Cellular and Molecular Medicine” This study using a mouse model reports that CuATSM treatment accelerates skin wound healing and reduces scar formation, with effects possibly mediated via the ferroptosis-induced Hippo/YAP signaling pathway and macrophage polarization, suggesting CuATSM as a potential therapy for scarless wound healing in clinical settings.
78 citations
,
April 1994 in “Archives of dermatology” This study suggests genetic and clinical heterogeneity in keratosis pilaris atrophicans, with variations in inheritance patterns, severity, and response to treatment among 21 individuals observed.
61 citations
,
September 2020 in “Bioactive Materials” This study found that the multifunctional FEA-PCEI dressing significantly accelerated wound healing, reduced scar formation, and promoted hair follicle neogenesis while providing antibacterial and anti-inflammatory benefits.
47 citations
,
September 2012 in “Human molecular genetics online/Human molecular genetics” This study suggests that the interaction between folliculin and plakophilin-4 (p0071) may play a role in folliculin's tumor suppressor function by regulating RhoA signaling, impacting cell migration and junction formation.
41 citations
,
April 2016 in “Journal of experimental botany” This research suggests that the barley protein RACB supports cell polarity functions rather than interfering with immunity, as it aids nucleus positioning during fungal attack rather than affecting early immune responses.
32 citations
,
December 2014 in “Cold Spring Harbor Perspectives in Medicine” This article reviews the role of polarity proteins in epidermal morphogenesis and homeostasis and discusses how their alteration may contribute to skin disease, but reports no new experimental findings.
29 citations
,
February 2013 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that Merkel cell clusters require Frizzled6 signaling for their polarity information, while other hair follicle-associated structures align their orientation based on the hair follicle itself.
28 citations
,
October 2014 in “Development” This study revealed that frizzled 3 can fully rescue polarity defects in frizzled 6-null mice, while frizzled 6 can partially rescue defects in frizzled 3-null mice, highlighting conserved signaling roles in these proteins.
23 citations
,
February 2015 in “The American journal of pathology” This study found that the absence of sebaceous glands may be an early factor in the development of keratosis pilaris, leading to hair shaft and skin barrier abnormalities, independent of filaggrin mutations.
22 citations
,
November 2024 in “Bioactive Materials” This study found that 3D-printed polyamine-modified hydrogels facilitate M2 macrophage polarization and exosome secretion, enhancing skin cell compatibility and promoting wound healing and hair follicle induction in an animal model through specific signaling pathways, suggesting potential for skin disorder therapies.