CuATSM Enhances Wound Repair Without Scarring via Hippo/YAP Signaling Pathway to Reduce Ferroptosis and Macrophage Polarization

    Yingdan Tang, Jiazong Ye, Tianchao Xu … Fangfang Wu
    Studysummary This study using a mouse model reports that CuATSM treatment accelerates skin wound healing and reduces scar formation, with effects possibly mediated via the ferroptosis-induced Hippo/YAP signaling pathway and macrophage polarization, suggesting CuATSM as a potential therapy for scarless wound healing in clinical settings.
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    Research cited in this study 6

    1. Inhibiting Dipeptidyl Peptidase 4 Positive Fibroblasts Using Zinc Sulfide Cellulose Nanofiber Scaffolds to Achieve Scarless Healing International Journal of Biological Macromolecules · 2024
    2. The Pioneer Factor SOX9 Competes for Epigenetic Factors to Switch Stem Cell Fates Nature cell biology · 2023
    3. Macrophage Related Chronic Inflammation in Non-Healing Wounds Frontiers in Immunology · 2021
    4. Scarless Wound Healing: Transitioning from Fetal Research to Regenerative Healing Wiley Interdisciplinary Reviews-Developmental Biology · 2018
    5. Wound Healing and Skin Regeneration Cold Spring Harbor Perspectives in Medicine · 2015
    6. Activated Hair Follicle Stem Cells and Wnt/β-Catenin Signaling Involved in Pathogenesis of Sebaceous Neoplasms International Journal of Medical Sciences · 2014