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Glossary Hippo signaling pathway

biological system controlling cell growth, division, and death

The Hippo signaling pathway is a biological system that controls cell growth, division, and death, playing a crucial role in regulating organ size and tissue regeneration. It involves a series of proteins that communicate signals from the cell surface to the nucleus, ensuring that cells stop growing when they reach a certain size, which helps prevent cancer and other diseases.

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Hippo pathway

Research

5 / 420 results

research CuATSM Enhances Wound Repair Without Scarring via Hippo/YAP Signalling Pathway to Reduce Ferroptosis and Macrophage Polarisation

3 citations , June 2025 in “Journal of Cellular and Molecular Medicine”

This study using a mouse model reports that CuATSM treatment accelerates skin wound healing and reduces scar formation, with effects possibly mediated via the ferroptosis-induced Hippo/YAP signaling pathway and macrophage polarization, suggesting CuATSM as a potential therapy for scarless wound healing in clinical settings.

research Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers

7 citations , August 2022 in “Experimental dermatology”

This review discusses the role of YAP/TAZ proteins in skin cancer physiology and tumorigenesis, and the potential of targeting these proteins in skin cancer treatments, but presents no new experimental findings.

research YAP1 promotes adipogenesis by regulating the negative feedback mechanism of the Hippo signaling pathway via LATS2

2 citations , January 2025 in “动物学研究”

In this study, overexpression of YAP1 was found to promote adipogenic differentiation of goat adipose-derived mesenchymal stem cells by up-regulating LATS2 expression and activating the Hippo pathway's negative feedback loop.

research YAP/TAZ Signalling Controls Epidermal Keratinocyte Fate

14 citations , November 2024 in “International Journal of Molecular Sciences”

This review summarizes existing evidence on how YAP and TAZ proteins are activated in epidermal keratinocytes and their role in coordinating with other signaling molecules to control transcription and influence epidermal cell fate, highlighting their importance beyond the Hippo pathway.

research Roles of Hippo signaling pathway in size control of organ regeneration

37 citations , April 2015 in “Development Growth & Differentiation”

This article introduces the concept of organ size control in regeneration, regulated by the Hippo signaling pathway, but reports no new experimental results.

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community Verteporfin and Microneedling

in Treatments 2 years ago

Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

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