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The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

The ZIP7 gene helps control zinc levels in cells by moving zinc from the Golgi apparatus to the cytoplasm.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

Thyroid function affects skin health, with a complex interaction between the two.

Thyroid hormone affects skin health, with too little causing rough, pale skin and too much leading to smooth, thin skin, and may also impact wound healing and skin conditions.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

Blocking a specific protein signal can make hair grow on mouse nipples.

Geranium sibiricum extract helps hair grow and is more effective than minoxidil but can be toxic in high concentrations.

A male with aromatase deficiency improved bone health with estradiol treatment.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Menopausal women have higher androgen levels, which can cause symptoms like facial hair growth and low sexual desire.

Testosterone therapy aims to treat hormone deficiencies and various conditions safely and effectively, but requires careful patient monitoring due to potential side effects.

Betacoronaviruses, like COVID-19, may cause hormone system dysfunction and affect disease susceptibility and severity.

Double-stranded RNA causes inflammation in hair follicle cells, which may help understand and treat alopecia areata.

New drugs are improving treatment for hormone-related diseases in small pets.

Leptin affects skin and hair health and may worsen some skin conditions, but more research is needed to understand its full impact.

Androgens and SARMs play a role in body mass, frailty, skin health, and hair growth, and are used in treating prostate cancer, acne, and hair loss, with potential for new uses and improved versions in the future.

Human scalp hair follicles can be used to study how prolactin affects hair growth and cell death.

Higher Lnk protein levels in ovaries may lead to insulin resistance in women with PCOS.

The document concludes that the hCG protocol may help in obesity treatment and could be scientifically justified, but more research is needed.

Finasteride affects frog testes by increasing testosterone, decreasing 5α-DHT, and impacting genes related to reproduction and other functions.

New treatments for long-lasting erections improve outcomes but must be timely to avoid lasting damage.

The conclusion is that certain genetic factors and blood types may affect COVID-19 severity, but changes in ACE2 and TMPRSS2 genes are not clearly linked to it.

Platelet-rich plasma therapy may have benefits and is generally safe, but more research is needed to confirm its effectiveness and safety.

Sex hormones affect reproduction, sexual development, and oral health, and it's important for dental practitioners to understand their effects and interactions.

Testosterone therapy can help improve sexual function, mood, and bone density in women with low androgen levels, but more research is needed on long-term safety.

Removing part of the vitamin D receptor stops vitamin D from working properly.