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research Sequential estrogen-progestin addition to gonadotropin-releasing hormone agonist suppression for the chronic treatment of ovarian hyperandrogenism: a pilot study.
This study concluded that a regimen of transdermal estradiol and oral medroxyprogesterone acetate effectively reduces hirsutism while minimizing side effects in women with polycystic ovary syndrome.
research In vivo differentiation of scarring alopecia using line‐field confocal optical coherence tomography: a pilot study
In this study, LC-OCT was used to distinguish between subtypes of scarring alopecia, laying the groundwork for further hypotheses and future research in larger and longitudinal studies to examine treatment responses.
research Mechanical stiffness across skin layers in human: a pilot study
In this study, researchers used atomic force microscopy to evaluate mechanical stiffness across different skin layers in six participants, finding the highest stiffness in the epidermis and lower stiffness as layers progress to subcutaneous tissue, enhancing understanding of skin's physical properties and aiding future research.
research A pilot study evaluating dosing tolerability of 17α-estradiol in male common marmosets (Callithrix jacchus)
research Effect of betulin oil on hair growth in hypothyroidism- a long-term blinded pilot study
In this pilot study, researchers found that betulin did not conclusively inhibit hair loss or promote regrowth in patients with hypothyroidism when compared to placebo.
research The effects of low-dose radiation therapy in patients with mild-to-moderate Alzheimer's dementia: an interim analysis of a pilot study
This study suggests that low-dose radiotherapy may lead to temporary neurological improvements in some Alzheimer's patients, with 20% showing cognitive improvement at 6 months; it was well-tolerated, though larger trials are needed for confirmation.
research Intradermal Injections of 10% Glucose (Sihler G) for Scalp Hair Regrowth: A Randomized, Evaluator-Blinded Pilot Study
This pilot study found that intradermal 10% glucose combined with non-cross-linked hyaluronic acid improved hair density and diameter more than hyaluronic acid alone in adults with androgenetic alopecia, with no serious adverse events.
research A 2% Oleosome-FGF-2 Fusion Extract Scalp Serum Improves Photo-trichogramDerived Hair Density, Anagen/Telogen Ratio, Hair Shaft Thickness, and Scalp Barrier Parameters in Women with Shedding-Prone Hair: A Randomized, SingleBlind, Placebo-Controlled Pilot Study
This exploratory pilot study reported that using a 2% Oleosome-FGF-2 fusion extract scalp serum twice daily for 84 days in women with telogen effluvium and brittle hair improved hair density, anagen/telogen ratio, hair shaft thickness, and scalp hydration compared to a placebo.
research Grading of Hirsutism in Females: A Pilot Study
In this study, researchers evaluated hirsutism in young females aged 18-24 using the modified Ferriman-Gallwey scoring system, finding that 52% showed mild to moderate-to-severe symptoms, often linked to menstrual irregularities and underlying endocrine disorders like polycystic ovary syndrome and thyroid issues.
research Early removal of post-operative scabs after follicular unit extraction using a 2% salicylic acid keratolytic shampoo: a multicentre descriptive pilot study
In this study, a keratolytic shampoo with 2% salicylic acid was found to effectively reduce scab severity in male patients after hair transplantation without causing adverse symptoms, leading to high patient satisfaction and no recorded adverse events.
research Progressive Zinc and Iron Deficiency Following Bariatric Surgery in Iraqi Patients: A 12-Month Pilot Study
This pilot study observed that post-bariatric surgery, both zinc and iron deficiencies increased among Iraqi patients, underscoring the importance of lifelong nutritional monitoring and targeted supplementation to address these issues and prevent related complications.
research Prevalence of rs1998076 and Its Association with Androgenetic Alopecia in Indonesian Population: A Pilot Study
In this pilot study of Indonesians, the rs1998076 genetic variant was not significantly linked to androgenetic alopecia, though the GG genotype showed a non-significant trend toward higher odds, while clinical factors like age and hypertension were correlated with increased risk.
research Hair Manganese as a Marker of Cardiometabolic Status Rather than Coronary Artery Disease Severity—An Exploratory Pilot Study
This study found that hair manganese levels did not vary by acute coronary syndrome or stable coronary artery disease severity, but a modest, non-significant correlation with body mass index suggests a potential link between manganese homeostasis and cardiometabolic status that warrants further investigation.
research Effectiveness of Abrocitinib in Adolescent Alopecia Areata: A Prospective Observational Pilot Study
This study found that abrocitinib showed promising efficacy and safety in adolescents with moderate-to-severe alopecia areata, with significant hair regrowth observed over 10 months of treatment.
research Preoperative Chronic Stress and Pain Outcomes: A Pilot Study of Hair Cortisol, Perceived Stress, and Chronic Post-Surgical Pain
Preoperative stress markers alone don't predict chronic post-surgical pain.
research Community Outreach for Hair Loss Education: A Pilot Feasibility Study
This pilot study reported that a community-based educational event in Winston-Salem, North Carolina, increased participants' understanding of hair loss conditions and confidence in using resources, leading 83% to say they were more likely to seek treatment for hair loss.
research Human insulin via MMP® for treating atrophic acne scars: a pilot study Insulina humana via MMP® para cicatrizes atróficas de acne: estudo piloto.
In this pilot study, patients with atrophic acne scars experienced clinical improvements and high satisfaction after receiving three biweekly microinfusions of human insulin into their skin.
research Aberrant B cell and cytotoxic T cell activation in female pattern hair loss: a pilot comparative clinico-transcriptomic study
Immune system issues may contribute to female pattern hair loss.
research Efficacy and safety of twice-weekly and thrice-weekly dutasteride compared to finasteride in men with androgenetic alopecia: A randomized, investigator-blind, active-controlled, parallel-group pilot study
In this study, twice-weekly and thrice-weekly dutasteride improved hair growth and were well-tolerated, although thrice-weekly dosing did not significantly outperform finasteride 1 mg daily for increasing hair count.
research Efficacy of Skin Patting and Iontophoresis with Dutasteride Gel in Male and Menopausal Female Androgenetic Alopecia: A Pilot Study
This pilot study found that using skin patting with iontophoresis to deliver dutasteride gel significantly improved hair density, shaft diameter, and pull test scores in men and postmenopausal women with treatment-resistant androgenetic alopecia, with participants reporting high satisfaction and no adverse events.
research Exploring the role of Kantavallabha rasa in Polycystic ovarian syndrome management: A pilot Study
In this pilot study, Kantavallabha rasa, an Ayurvedic medicine, showed significant improvements in PCOS symptoms such as menstrual irregularities, pain, unwanted hair growth, skin issues, and ovarian conditions among 10 women with PCOS.
research Nanostructured Ayurvedic Emulsion of Bakuchiol & Neem Oil for Mild‑to‑Moderate Alopecia Areata Open‑Label Single‑Arm Pilot Study
This pilot study found that a novel nanoemulsion with Bakuchiol and Neem oil significantly improved hair regrowth in adults with Alopecia Areata without serious side effects, providing a promising natural alternative.
research Novel Electrotrichogenic Device Promotes Hair Growth in Men With Androgenetic Alopecia: A Pilot Study
In this pilot study, the niostem device, a wearable device delivering low-level electrical stimulation, significantly increased hair density by 19.3% and thickness by 8.8% in male androgenetic alopecia patients over six months without reported adverse events.
research Additional Intraoperative Autologous-Derived Platelet-Rich Stroma to Transanal Flap Repair for the Treatment of Cryptoglandular Transsphincteric Fistulas in a Tertiary Referral Center: Long-Term Outcomes of a Prospective Pilot Study
This study evaluated the long-term effects of combining autologous platelet-rich stroma injection with transanal advancement flap repair for cryptoglandular transsphincteric fistulas and found that it resulted in primary clinical closure and radiological healing in a high percentage of patients, with low recurrence rates.
research Efficacy of Skin Patting and Iontophoresis with Dutasteride Gel in Male and Menopausal Female Androgenetic Alopecia: A Pilot Study
This pilot study found that using skin patting and iontophoresis to deliver a 6% dutasteride gel led to significant improvements in hair density and shaft diameter in men and postmenopausal women with treatment-resistant androgenetic alopecia, with no reported adverse events.
research Dermoscopy as a novel tool to examine and assess treatment response of acne scars: A pilot study in an Indian population
The researchers observed that dermoscopy is valuable for assessing acne scars and their response to treatment, with shorter-duration scars responding more effectively.
research Musculoskeletal and body composition response to high-dose testosterone with finasteride after chronic incomplete spinal cord injury—a randomized, double-blind, and placebo-controlled pilot study
In this pilot randomized clinical trial, TRT combined with finasteride increased lean mass, muscle size, and bone mineral density without prostate enlargement in men with spinal cord injury, suggesting potential benefits for body composition and musculoskeletal health.
research Comparative analysis of temperature‐controlled cryotherapy versus intralesional triamcinolone acetonide injection for alopecia areata: An intrasubject split‐lesion pilot study
In this pilot study, cryotherapy using a device that precisely controls cooling duration improved hair regrowth for patchy alopecia areata when applied for 20 seconds with two freeze-thaw cycles, similar to standard triamcinolone acetonide injections, but not when applied for 10 seconds.
research Ayurvedic Management of Osteoporosis W.S.R. to Asthikshaya- A Pilot Study
In this clinical study, 15 patients with osteoporosis treated with the Ayurvedic formulation Asthiposhtika Vati showed improvements in symptoms, suggesting its effectiveness in managing the condition.