Efficacy of Skin Patting and Iontophoresis with Dutasteride Gel in Male and Menopausal Female Androgenetic Alopecia: A Pilot Study

    September 2025 in “ Dermatology and Therapy
    Stephano Cedirian, Francesca Pampaloni, Federico Quadrelli, Luca Rapparini, Francesca Bruni, Ginevra Martelli, Bianca Maria Piraccini, Michela Starace
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    TLDR The treatment improved hair growth and was well-received without side effects.
    This pilot study explored the use of a 6% dutasteride gel applied through skin patting and iontophoresis in 20 adults with treatment-resistant androgenetic alopecia. The results showed significant improvements in hair density, shaft diameter, and reduced hair shedding, with 70% of participants finding the treatment effective and 85% describing it as pleasant. No adverse events were reported. The study indicates that this method enhances local anti-androgen effects while minimizing systemic exposure. However, limitations include the small sample size, open-label design, lack of a comparator arm, short follow-up, and non-validated outcome measures, necessitating larger randomized trials for confirmation.
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