Nanostructured Ayurvedic Emulsion of Bakuchiol and Neem Oil for Mild-to-Moderate Alopecia Areata Open-Label Single-Arm Pilot Study

This pilot study evaluated a novel nanoemulsion containing Bakuchiol (1%) and Neem oil (3%) for treating mild-to-moderate Alopecia Areata in 30 adults. Applied twice daily for 12 weeks, the treatment significantly increased hair density by 25% and reduced the Severity of Alopecia Tool (SALT) score by 33%, indicating clinical improvement. Dermoscopic analysis showed increased terminal hair count and reduced dystrophic signs. Patient satisfaction was high, with 85% rating their outcome as "good" or "very good." The formulation was well-tolerated, with only mild scalp tingling in 10% of participants. The study suggests that combining Ayurvedic ingredients with nanotechnology is a promising alternative for Alopecia Areata management, though further trials with larger populations are needed.