35 citations
,
December 1979 in “Naunyn-schmiedebergs Archives of Pharmacology” These drugs raise prostaglandin-like material in dog blood, possibly causing blood vessel widening.
34 citations
,
February 2018 in “Drug Design Development and Therapy” This source reports that bimatoprost, a medication approved for eyelash growth, has shown efficacy in treating eyebrow hypotrichosis, suggesting it as a noninvasive, effective, and well-tolerated option for enhancing eyebrow hair.
29 citations
,
January 2016 in “Annals of dermatology/Annals of Dermatology” This study found that arachidonic acid may promote hair growth by enhancing dermal papilla cell function and stimulating the anagen phase in C57BL/6 mice.
28 citations
,
December 2019 in “Skin appendage disorders” This review discusses medication-induced gray hair repigmentation, highlighting that certain anti-inflammatory drugs and melanogenesis stimulators can cause diffuse repigmentation, though evidence remains low-quality and these medications are not currently indicated for this purpose.
28 citations
,
February 2016 in “F1000Research” This review introduces an integrated view of hair follicle behavior, highlighting a Yin Yang model of regulation and suggesting glycans as key elements in hair follicle growth control, without reporting new clinical findings.
26 citations
,
January 2019 in “Expert Opinion on Investigational Drugs” This review explored the new and emerging treatments for androgenetic alopecia and alopecia areata, finding that JAK inhibitors show promise for alopecia areata, while advancements in stem-cell research may eventually lead to new and improved treatments for androgenetic alopecia.
25 citations
,
July 2017 in “Archives of Dermatological Research” This review summarizes preclinical and clinical information on herbal products for hair loss treatment, highlighting their mechanisms, follicular penetration, and potential side effects, suggesting they may offer alternatives to synthetic drugs with fewer side effects.
25 citations
,
March 2017 in “Experimental Dermatology” This review discusses various aspects of hair follicle biology and highlights unresolved questions and potential new research avenues, but presents no new experimental findings.
24 citations
,
August 2017 in “Prostaglandins & Other Lipid Mediators” This review discusses the potential roles of prostaglandin D2 and its receptor CRTH2 in various diseases beyond allergies and asthma and reports no new clinical results.
24 citations
,
May 2018 in “Journal of Molecular Endocrinology” This article discusses the discovery of the first known menstruating rodent, the spiny mouse, and proposes that a significant increase in progesterone during the luteal phase is a unique feature of menstruating species, but reports no new experimental results.
23 citations
,
August 2018 in “Biochimica and biophysica acta. Molecular and cell biology of lipids” This article reviews the roles of lesser-known secreted phospholipase A2 isoforms in various biological processes, such as immune suppression, metabolic regulation, epidermal hyperplasia, and male reproduction, without reporting new clinical findings.
23 citations
,
March 1988 in “Biochemical Pharmacology” This study found that minoxidil inhibited prostacyclin production in various endothelial and smooth muscle cells in culture without affecting the synthesis of other cyclooxygenase products.
22 citations
,
August 2017 in “Stem cells and cloning” This review analyzes therapies used for androgenic alopecia, highlighting potential advances from stem cell technologies and regenerative medicine, and reports no new clinical results.
20 citations
,
January 2017 in “Actas Dermo-Sifiliográficas” This review discusses recent therapeutic advances in treating various types of hair loss, including androgenetic alopecia, alopecia areata, frontal fibrosing alopecia, and hair transplant technologies, but reports no new clinical results.
20 citations
,
May 2023 in “Biological Trace Element Research” This study found that repeated oral intake of 0.5 or 5 mg/kg of cobalt ferrite nanoparticles induced pulmonary toxicity in rats, with dose-dependent oxidative stress and inflammation observed, but no notable toxicity was seen at a 0.05 mg/kg dose.
20 citations
,
July 2020 in “Expert Opinion on Biological Therapy” This study found that combining micro-needling, low-level laser therapy, and autologous non-activated platelet-rich plasma increased hair density in patients with androgenic alopecia over the treatment period.
19 citations
,
August 2019 in “Expert Opinion on Therapeutic Targets” This review discusses emerging targets for developing drugs to treat hair loss and reports no new clinical results; the authors emphasize the potential for therapies that regenerate hair follicles.
19 citations
,
April 2015 in “European Journal of Pharmacology” This study found that dihydrotestosterone (DHT) may shorten the hair growth cycle through mechanisms like cell-cycle arrest and β-catenin downregulation in rat hair follicle cells.
18 citations
,
November 2020 in “Frontiers in Cell and Developmental Biology” This review discusses how inflammation influences hair follicle stem cell activities like wound healing and follicle cycling and suggests a potential link between inflammation, stem cell activation, and programmed cell death.
17 citations
,
August 2015 in “Expert Opinion on Pharmacotherapy” This article discusses the social and psychological impact of hair disorders and the challenges in their treatment, but reports no new clinical results.
17 citations
,
March 2021 in “Expert Opinion on Biological Therapy” This review analyzes the impact of different preparation methods for platelet-rich plasma, human follicles stem cells, and adipose-derived stem cells on hair regrowth and wound healing, but reports no new results; the authors emphasize convincing evidence of positive outcomes despite protocol variability.
15 citations
,
September 2005 in “The Journal of the American Animal Hospital Association/Journal of the American Animal Hospital Association” This study found that trilostane treatment led to complete hair regrowth in three Alaskan malamutes with ACTH-stimulated elevated 17-hydroxyprogesterone levels within 6 months without any recognized adverse effects.
14 citations
,
August 2013 in “Facial Plastic Surgery Clinics of North America” This review discusses current and emerging medical therapies for androgenetic alopecia but reports no new clinical findings, emphasizing the importance of stabilizing the condition as a complement to surgical hair restoration.
11 citations
,
July 2017 in “Expert Opinion on Investigational Drugs” This review discusses current and emerging therapeutic strategies for androgenetic alopecia, noting limited evidence but suggesting areas such as prostaglandin analogs, PRP, and progenitor cell therapies as promising future directions.
11 citations
,
September 2013 in “Journal of the Egyptian Women's Dermatologic Society (Print)” Various treatments exist for hair loss, but more research is needed for better options.
11 citations
,
August 2012 in “Canadian journal of ophthalmology” This study found that among patients with eyelash alopecia areata, 40% experienced complete regrowth of lashes, with a mean time to regrowth of 28 months.
10 citations
,
September 2020 in “Archives of Dermatological Research” Both methods improve hair density and thickness; double-spin may be more effective.
10 citations
,
January 2019 in “Journal of Chromatography B” This study used a newly validated method to find that one-year finasteride treatment resulted in no significant differences in urinary androgen and prostaglandin levels between male pattern baldness patients and normal controls.
10 citations
,
September 2018 in “Regenerative Medicine” This review explores the mechanism and potential applications of wound-induced hair follicle neogenesis but reports no new clinical results, highlighting the need for further research in hair regeneration therapies.
10 citations
,
January 1985 in “Elsevier eBooks” Active oxygen species might be involved in skin tumor growth, but their exact role is unclear.