53 citations
,
September 2011 Other common signs, not just the well-known immune cells around hair bulbs, are important for diagnosing hair loss from alopecia areata.
19 citations
,
September 2014 in “JAMA Dermatology” Eosinophilic infiltrate is not a reliable indicator for diagnosing chronic alopecia areata.
April 2020 in “International Journal of Dermatology” This study found that peribulbar lymphocytic infiltration can effectively differentiate between alopecia areata and androgenetic alopecia using T-cell infiltration patterns in skin tissue.
43 citations
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May 2011 in “Dermatologic Therapy” This article discusses the phases and histological features of alopecia areata and reports no new clinical findings; the authors emphasize recognizing these phases for accurate diagnosis.
23 citations
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September 2019 in “Dermatology practical & conceptual” This study analyzed the features of alopecia areata incognita and diffuse alopecia areata, finding distinct patterns in hair loss regions and trichoscopic signs, and noted a benign course responsive to topical steroid therapy.
18 citations
,
April 2010 in “Archives of Dermatology” This case report describes a patient with psoriasis and alopecia universalis where psoriasis plaques supported hair growth, suggesting cytokine interaction may influence competing immune responses.
9 citations
,
January 2010 in “International Journal of Trichology” This study found that in Alopecia Areata, increased non-anagen terminal follicles and peribulbar lymphocytic infiltrate are consistent histological features, even in cases that have progressed to scarring.
8 citations
,
June 2012 in “Australasian Journal of Dermatology” In this study, two patients with localized hair thinning showed histopathological signs typical of alopecia areata, responding to corticosteroid treatment similarly to classical cases.
7 citations
,
January 2012 in “International Journal of Trichology” This article highlights differences in childhood alopecia areata compared to adult cases but reports no new clinical findings.
6 citations
,
March 1999 in “Seminars in Cutaneous Medicine and Surgery” This report presents four cases highlighting diagnostic challenges between specific types of alopecia, comparing their clinical and histopathologic features without providing new research findings.
1 citations
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October 2013 in “BMJ” This case study reports a man with rapid hair thinning, whitening, and sparse beard, linked to an increased proportion of hair follicles in catagen or telogen phase and peribulbar lymphocytic infiltrate.
January 2012 in “Yearbook of Dermatology and Dermatologic Surgery” The study concluded that a 'Swiss cheese' pattern in hair follicles is a useful sign for diagnosing alopecia areata.
January 2026 in “International Research Journal of Modernization in Engineering Technology and Science” This review outlines the existing understanding of alopecia areata, detailing its autoimmune nature, clinical presentation, histology, and management strategies, with corticosteroids highlighted as the most popular treatment option.
May 2023 in “Tạp chí Da liễu học Việt Nam” This study involving Vietnamese patients with alopecia areata found that histopathological examination is crucial for diagnosis, noting diverse features including peribulbar lymphocytic infiltration and varying hair follicle characteristics across disease stages, with eosinophils and necrosis observed in some cases.
January 2015 in “Indian Dermatology Online Journal” This diagnostic discussion reports that diffuse alopecia areata was identified in a patient with diffuse hair loss, based on specific histopathological features observed in a biopsy.
January 2024 in “Pan African Medical Journal” This study aimed to document and compare the prevalence and characteristics of hair loss in patients with systemic lupus erythematosus, noting the differences in trichoscopic and histopathologic evaluations between those with and without alopecia. Results are not reported.
1 citations
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September 2021 in “Journal of The American Academy of Dermatology” This study observed that inflammation in androgenetic alopecia samples was similar to alopecia areata controls, but infundibular and isthmic inflammation were significantly more common in androgenetic alopecia cases.
16 citations
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February 1999 in “American Journal of Dermatopathology” This article describes a woman's case of slowly progressive nonscarring alopecia with unique biopsy findings, suggesting the need to reexamine similar cases currently classified as chronic diffuse alopecia areata.
April 2012 in “Informa Healthcare eBooks” Syphilitic alopecia is a rare hair loss condition in secondary syphilis that looks similar to another condition but can be diagnosed with specific tests and responds to antibiotics.
July 2004 in “Dermatologic Surgery” This study identified acute localized telogen effluvium as a potential cause of temporal hair loss following rhytidectomy.
January 2023 in “Journal of Cutaneous Pathology” This study found that histopathologic features such as a catagen/telogen shift, melanin in fibrous tracts, and small dystrophic follicles can help differentiate alopecia areata from pattern hair loss in the absence of peribulbar infiltrates.
35 citations
,
November 2010 in “Journal of Cutaneous Pathology” This study reported that dilated follicular infundibula are a highly useful histopathologic criterion for diagnosing alopecia areata, particularly during its recovery stage.
3 citations
,
January 2019 in “Indian Journal of Dermatology” This study observed that transverse sectioning of scalp biopsies may aid in diagnosing different types of alopecia by revealing distinct histopathological features like follicle miniaturization and specific inflammatory patterns.
7 citations
,
January 2009 in “Immunological investigations” This report describes a rare case of alopecia areata universalis developing in a child during the recovery phase of phenobarbital-induced anti-convulsant hypersensitivity syndrome, which suggests a mechanism involving lymphocyte-related immune responses.
18 citations
,
January 2017 in “Annals of dermatology/Annals of Dermatology” This study found that Th17 lymphocytes may play a more crucial role than cytotoxic T cells in the development of alopecia areata due to their infiltration around the hair bulb/bulge, which exacerbates hair loss as histopathological grade worsens.
7 citations
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August 2019 in “American Journal of Dermatopathology” This study found that limb hair loss in frontal fibrosing alopecia is inflammatory and permanent, but lacks the classic scarring features seen in scalp alopecia, prompting potential misdiagnosis as alopecia areata.
19 citations
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March 2003 in “Journal of Investigative Dermatology” This study found that mechlorethamine restored hair growth in mice with alopecia-areata-like disease by eliminating infiltrated lymphocytes and inhibiting certain pro-inflammatory cytokines in treated skin areas.
19 citations
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March 1997 in “Journal of Cutaneous Pathology” This study observed that patients with alopecia areata often have a T-cell receptor repertoire in skin lesions that suggests a specific antigen-driven immune response may be important in the disease's pathogenesis.
29 citations
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March 2001 in “Clinics in Dermatology” This article discusses various types of primary cicatricial alopecias and reports no new clinical results; it emphasizes the importance of accurate diagnosis for effective management.
19 citations
,
February 2016 in “Journal of The American Academy of Dermatology” This study found that the presence of CD3(+) T-cells within empty follicular fibrous tracts is a reliable indicator for diagnosing diffuse alopecia areata instead of pattern hair loss.