Frontal Fibrosing Alopecia: A Review of Eleven Patients

    September 2011 in “ European Journal of Dermatology ”
    Isabel Fernandes, Manuela Selores, Susana Machado
    Image of study
    TLDR Most treatments for Frontal Fibrosing Alopecia are ineffective, but early anti-inflammatory therapy may help and the condition may stabilize over time.
    The document summarizes a study of 11 patients with Frontal Fibrosing Alopecia (FFA), a condition marked by a receding frontotemporal hairline, which is a variant of lichen planopilaris. The study, conducted over three years, involved ten postmenopausal and one premenopausal women aged between 45 and 80. Clinical observations included symmetrical frontal and temporal alopecia, with eyebrow and axillary hair loss in some patients. Normal laboratory results were reported, and scalp biopsies indicated perifollicular fibrosis and lymphocytic inflammation. Treatments like intralesional corticosteroids and hydroxychloroquine were largely ineffective, except for one recent case showing some improvement. The study concluded that there is no strongly evidenced effective treatment for FFA, though early anti-inflammatory therapy might help, and the condition often stabilizes on its own after a few years.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 393 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Fibrosing alopecia in a pattern distribution

      in Research/Science  14 upvotes 9 months ago
      A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

      community I think I’ve finally found the reason for my hair loss

      in Chat  98 upvotes 2 weeks ago
      The user experienced hair loss since 2019 and tried finasteride, dutasteride, RU58841, and ketoconazole shampoo without success. A scalp biopsy showed scarring and inflammation from folliculitis, indicating chronic inflammation was affecting treatment effectiveness.

      community 9 months on Fin - no progress , should I get on Dutasteride?

      in Chat  10 upvotes 1 month ago
      The user has been using finasteride, minoxidil, and nizoral for hair loss but hasn't seen regrowth, only maintenance. They are considering switching to dutasteride, which is believed to be more effective, but are concerned about potential side effects.

      community Testosterone and hair loss seeming irrelevance

      in Research/Science  81 upvotes 1 year ago
      The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

      community I tried salt water to stop the DHT itch

      in Treatment  60 upvotes 2 years ago
      Treating the itch associated with male pattern baldness, which is believed to be caused by DHT. Potential treatments discussed include salt water, finasteride, ketoconazole, and RU58841.

    Related Research

    7 / 7 results