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The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Different types of stem cells and their environments are key to skin repair and maintenance.

Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

New treatments targeting specific genes show promise for treating keratin disorders.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

UV radiation can help sterilize wounds and promote healing but requires careful use to avoid damaging cells.

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.

Sponge helps heal wounds faster with less inflammation and better skin/hair growth.

Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

Mesenchymal stem cells show potential for skin healing and anti-aging, but more research is needed for safe use, especially regarding stem cells from induced pluripotent sources.

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

Mushrooms have beneficial properties for skin and hair care products and have great potential for future cosmetic use.

A protein called CBP is found in prostate cancer and can increase the effectiveness of certain prostate cancer treatments.

The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Platelet preparations generally show positive effects on wound healing and facial rejuvenation, but more thorough research is needed to confirm their effectiveness.

Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.