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The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.

Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Changing the environment around stem cells could help tissue repair, but it's hard to be precise and avoid side effects.

Stress can worsen skin and hair conditions by affecting the skin's immune response and hormone levels.

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

Different types of fibroblasts play various roles in diseases and healing, and more research on them could improve treatments.

The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

Some medicinal plants can help heal wounds and may lead to new treatments.

Scientists found a new, less invasive way to study body clocks using hair cells, which shows shift workers' body clocks don't match their lifestyles.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Liposomes improve drug delivery and reduce skin irritation in dermatology.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Women with PCOS and higher androgen levels are more likely to have fatty liver disease.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.

Oral retinoids are effective for various skin conditions but have side effects and should not be used during pregnancy.

Skin surface lipids are important for skin health and altering them could help prevent aging and treat skin conditions.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

Improving skin barrier and using antifungal treatments can help manage dandruff.

Skin has specialized touch receptors that can tell different sensations apart.

Restoring mitochondrial function in mice reversed their skin wrinkling and hair loss.

Toxic epidermal necrolysis is a severe skin condition often caused by drugs, with complex treatment and a high risk of death, but survivors usually heal without scars.

Some heart drugs show promise for other conditions, but more research is needed to confirm their effectiveness and safety.