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Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

β-catenin is essential for stem cell activation and proliferation in hair follicles.

The nanofibers with two growth factors improved wound healing by supporting structure, preventing infection, and aiding tissue growth.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

Horizontal scalp biopsy sections effectively diagnose and predict MPAA, with follicular density and inflammation impacting hair regrowth.

The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.

The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.

Removing part of the vitamin D receptor stops vitamin D from working properly.

The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.

Apoptosis is essential for human skin development and forming a functional epidermis.

Wnt1/βcatenin signaling is crucial for heart repair after injury.

Ectodin integrates BMP, SHH, and FGF signals in developing ectodermal organs.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.

Finasteride doesn't effectively treat hair loss in postmenopausal women.

The timing of when the gene Bmal1 is active affects aging and survival, with its absence during development, not adulthood, leading to premature aging.

Hair growth and pigmentation in mice involve specific stages crucial for research.

Two main types of fibroblasts with unique functions and additional subtypes were identified in human skin.

Tofacitinib is safe and effective for severe alopecia areata, but hair loss may return 2 months after stopping treatment.

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Tiny pollution particles called PM2.5 can harm skin cells by causing stress, damage to cell parts, and cell death.

Sorafenib is effective in treating Desmoid Tumor/Deep Fibromatosis.

The document provides a method to classify human hair growth stages using a model with human scalp on mice, aiming to standardize hair research.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Scientists have found a way to create hair follicles from skin cells of newborn mice, which can grow and cycle naturally when injected into adult mouse skin.

Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.

Lactate production is important for activating hair growth stem cells.

The hedgehog signaling pathway is crucial for hair growth but not for the initial creation of hair follicles.

Hair follicle development and microbes help regulatory T cells gather in newborn skin.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.