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In this case report, a three-generation family with Gorlin-Goltz syndrome showed a heterozygous PTCH1 splice-donor variant associated with the disease, and two affected relatives benefited from individualized, side-effect-guided dosing of the drug sonidegib, experiencing regression of basal cell carcinoma lesions.

This study found that ERBB2 mutations and amplifications are likely key drivers of extramammary Paget disease, suggesting potential for targeted therapies and cancer immunotherapy due to the moderately high mutational load observed.

This letter reports a woman with nevoid basal carcinoma syndrome and pronounced androgenic alopecia associated with a novel PTCH gene mutation p.Leu1159fsx32, suggesting a genetic link in this case study.

In this research, most cases of mammary and extramammary Paget disease were reported to express PRAME, expanding the understanding of its presence in cutaneous epithelial tumors, though its diagnostic utility is limited by overlap with other conditions.

This case report describes an 8 cm giant pilomatricoma on a 67-year-old man's scalp, revealing distinct transcriptional patterns related to hair follicle factors and keratin through spatial gene expression analysis.

This case report documented a novel presentation of a canine viral plaque appearing as a solitary exophytic keratin-filled mass, highlighting the need to differentiate it from a hair follicle tumor.

This article reviews the characteristics and presentation of fibrosing alopecia in a pattern distribution, a form of scarring alopecia similar to androgenetic alopecia and lichen planopilaris, but provides no new clinical findings.

This study focused on equine sarcoid, the most common tumor in horses, and described its types, clinical signs, and histopathological characteristics such as hyperkeratosis and changes in the hair follicle and dermis.

This case report described a facial hairline tumor initially diagnosed as a sebaceous cyst but ultimately confirmed as a rare Proliferating Pilar Tumor with focal malignancies upon histopathological examination.

In this report, a 2-year-old male with GAPO syndrome exhibited androgenetic-like alopecia with normal testosterone levels and telogen hair loss, which are novel findings for this condition.

This study observed that fibrosing alopecia in a pattern distribution shows varied histological features and may resemble lichen planopilaris with initial diffuse distribution, potentially leading to scarring alopecia.

Early diagnosis of pseudopelade of Brocq in men is crucial to prevent permanent hair loss.

Fibrosing alopecia in a pattern distribution is a unique hair loss condition with inflammation and scarring, resembling but distinct from common balding.

A man had a non-cancerous, fast-growing skin lump on his arm that was removed with surgery.

This study found that the distribution of mast cell prostaglandin d-synthase in the scalp spatially aligns with the pattern of androgenetic alopecia, suggesting a programmed vulnerability to hair loss.

This article reports on lentiginosis observed within plaques of linear atrophoderma of Moulin and discusses its potential classification as a twin-spotting phenomenon but provides no new clinical research results.

In this study, researchers identified a recurrent MBTPS2 splice-site variant as a mutational hotspot in IFAP syndrome across diverse families, with phenotype severity suggesting the influence of additional modifiers.

This review discusses fibrosing alopecia in a pattern distribution and highlights diagnostic features, but reports no new clinical results; the authors emphasize the value of trichoscopy and histology in diagnosis.

A teenager's hair with alternating white and dark bands, known as Pili annulati, is a genetic condition that is usually harmless and often considered attractive.

This study found that several genes, including capping protein, palladin, VEGF, and HSPC-related clones, might cooperatively influence the aggregation, proliferation, and cycle control of dermal papilla cells, potentially affecting hair follicle behavior.

In this case report, a rare instance of a primary cutaneous granular cell tumor with prominent overlying terminal hair growth in an adult is described, highlighting the importance of recognizing atypical presentations to accurately diagnose similar uncommon neoplasms.

This study describes a functional disorder in the ovary, known as stromal hyperplasia, characterized by the proliferation of ovarian stroma and luteinization of stromal cells, which is linked to excessive androgen production and elevated testosterone levels.

This case report identifies a 32-year-old woman with undiagnosed PHPT-1a who exhibited complete pseudo-anodontia and persistent patchy alopecia areata, suggesting these may be new nonclassical features of a GNAS pathogenic variant.

This study found that in a mouse model of Gorlin syndrome, constitutive activation of signaling in dermal cells led to abnormal follicular growth, indicating non-epidermal factors may contribute to the disease.

This case study reports that a heterozygous missense GJA1 mutation, p.Gly138Ser, in a 2-year-old boy with oculodentodigital syndrome primarily resulted in syndactyly, fifth finger hypoplasia, and hypotrichosis, without neurological or craniofacial abnormalities.

This case report describes a 26-year-old woman with a giant cell tumor in the left proximal fibula, presenting atypically alongside pseudopseudohypoparathyroidism features, which remain rare in such contexts.

This case report describes the first observed instance of fibrosing alopecia in a pattern distribution in a child, suggesting the condition is not solely androgen dependent.

The Trichodysplasia spinulosa virus protein can cause abnormal hair growth in mice.

This case report illustrates that fibrosing alopecia in a pattern distribution may be misdiagnosed as androgenetic alopecia due to similar hair loss patterns, but distinctive trichoscopic and histopathologic features help differentiate it.

This study found that clinically non-affected perilesional scalp in Japanese alopecia patients often showed microscopic abnormalities, which may help in assessing the spread of disease activities.