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The p53 protein helps control hair follicle shrinking by promoting cell death in mice.

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.

Lactate production is important for activating hair growth stem cells.

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

Advanced human skin models improve drug development and could replace animal testing.

Zebrafish larvae are used to study and find treatments for ear cell damage because they are easier to observe and test than mammals.

MicroRNAs are important for skin health and could be targets for new skin disorder treatments.

Plant extracts can help prevent hair loss and promote hair growth.

Certain natural and synthetic compounds may help treat inflammatory skin diseases by targeting a specific signaling pathway.

Certain mouse strains develop a skin condition similar to a human hair loss disease due to genetic defects.

Eating fewer calories may slow skin aging and improve skin health through various biological changes.

Deleting the Trf1 protein in mice is safe and may help prevent cancer without major side effects.

HPV genes in mice improve ear tissue healing by speeding up skin growth and repair.

Keratin 17 is important for skin's response to radiation, affecting many genes and cell division.

Hair grows faster in the morning and is more vulnerable to damage from radiation due to the internal clock in hair follicle cells.

Maintaining DNA health in stem cells is key to preventing aging and tissue breakdown.

Mice that can regenerate tissue have cells that pause in the cell cycle, which is important for healing, similar to axolotls.

Rapamycin reduces skin cell growth and tumor development by affecting cell signaling in mice.

Removing centrosomes from skin cells leads to thinner skin and stops hair growth, but does not greatly affect skin cell differentiation.

The document suggests that activating autophagy might help with regeneration by removing old and damaged cells.

Mice lacking a key DNA methylation enzyme in skin cells have a lower chance of activating stem cells necessary for hair growth, leading to progressive hair loss.

Vav2 changes how hair follicle stem cells' genes work as they age, which might improve regeneration but also raise cancer risk.

TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.

Gene therapy shows promise for treating skin disorders and cancer, but faces technical challenges.

ΔNp63α stops TAp73β from working in skin cancer by blocking its access to specific genes, not by directly interacting with it.

Integrin alphavbeta6 is important for wound healing and hair growth, and blocking it may improve these processes.

The study concludes that the EDA2R gene is activated by p53 during chemotherapy but is not necessary for chemotherapy-induced hair loss.

Hair loss and aging are caused by the breakdown of a key protein in hair stem cells.