19 citations
,
December 2015 in “Journal of Investigative Dermatology” This study found that keratin 17 expression is initially down-regulated and later strongly up-regulated by ionizing radiation in a rat model, with p53 repressing early transcription.
29 citations
,
January 2017 in “Journal of Investigative Dermatology” This study found that increased MSI2 expression in hair follicle stem cells can delay hair growth by maintaining stem cell quiescence and repressing Hedgehog signaling.
11 citations
,
August 2021 in “Aging” This study found that TGF-β2 may enhance collagen expression and spheroid formation in human dermal papilla cells, which could improve their hair inductivity and maintenance.
January 2026 in “Aging and Disease” This study found that, despite confirming MC1R expression and functional cAMP signalling, α-MSH treatment did not alleviate UVA-induced stress in adult dermal fibroblasts, suggesting that α-MSH-MC1R may not directly protect against UVA-induced photoaging in these cells.
31 citations
,
November 2015 in “PloS one” In this study, modulating Tyrosinase expression altered mouse coat color by affecting melanosome accumulation, indicating that melanosome maturity plays a role in determining skin and hair color beyond total melanin content.
41 citations
,
January 2007 in “Journal of Korean Medical Science” This study found that combining minoxidil with all-trans retinoic acid additively promoted hair growth in vitro by activating certain cell survival pathways and reducing apoptosis markers more effectively than minoxidil alone.
This study found that enhancing quercetin bioavailability with EubioQuercetin significantly improved external aging signs in mice and influenced gut microbiota and intestinal gene expression, suggesting potential modulation through the gut microbiota–intestinal barrier axis.
1 citations
,
November 2025 in “Clinical and Experimental Medicine” This review highlights the emerging role of long non-coding RNAs (lncRNAs) in dermatology, suggesting that lncRNAs significantly impact signaling pathways involved in normal skin functions and skin diseases, offering potential as biomarkers and therapeutic targets.
1 citations
,
April 2015 in “InTech eBooks” RAGE is a potential target for melanoma treatment, but its effectiveness is uncertain due to variable expression levels.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that age-related changes in scalp dermal fibroblasts, including increased MMP-1 and reduced ECM components, may significantly affect the hair follicle environment and contribute to hair aging.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study describes a new method for isolating intact human eccrine glands from scalp follicular units, potentially advancing research on sweat gland physiology.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that GATA6 is a key regulator of the upper pilo-sebaceous unit homeostasis and differentiation in human skin.
2 citations
,
November 2019 in “Cancer reports” This study concluded that the Wnt signaling pathway does not significantly influence human keratoacanthoma development, but the overexpression of Sox9 suggests alternate signaling involvement.
56 citations
,
March 2015 in “Cell death and differentiation” This study found that H-Ras activation in aged mouse skin leads to increased dysplasia and progression to in situ squamous cell carcinoma, highlighting an age-linked connection between immune changes, senescence, and cancer risk.
1 citations
,
April 2016 in “Journal of Investigative Dermatology” This study identified that blocking the PTGDR2 receptor in human hair follicles in vitro and in mice reversed the hair growth inhibition caused by PGD2, suggesting a potential approach for treating alopecia.
April 2016 in “Journal of Investigative Dermatology” This study provides a comprehensive platform to explore stem cell interactions regulating hair follicle growth, revealing key signaling pathways in epithelial-mesenchymal interactions using advanced RNA sequencing and transgenic reporters.
70 citations
,
January 2014 in “International review of cell and molecular biology” This review discusses the role of keratins in maintaining epidermal structure and function and reports no new results; the authors emphasize the lack of rational therapies for skin disorders linked to keratin mutations.
50 citations
,
September 2023 in “Biomarker Research” This review focuses on S100A6, a Ca²⁺-binding protein, detailing its role in cell functions, the regulation of its expression, and its potential as a biomarker and therapeutic target in various diseases.
35 citations
,
July 2018 in “Cell Reports” This study found that the dermal papilla of the hair follicle regulates stem cell quiescence and regeneration by modulating Shh and Wnt signaling pathways, highlighting the importance of signaling cross talk in regeneration.
32 citations
,
November 2016 in “Journal of Dental Research” This review explores the role of Panx3 in skeletal formation and discusses its potential in developing new therapies for conditions like osteoarthritis, without presenting new clinical findings.
29 citations
,
March 2015 in “Journal of Investigative Dermatology” This study provides evidence that Cyclosporine A inhibits catagen development in human hair follicles, suggesting different underlying mechanisms from those observed in rodent studies.
26 citations
,
July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, loss of epidermal Par3 in mice disrupted the skin barrier and affected cell differentiation and stem cell maintenance, highlighting its role in epidermal homeostasis.
24 citations
,
July 2018 in “Stem cells” This study found that Runx1 in hair follicle stem cells modulates lipid metabolism, impacting membrane organization and enhancing signal transduction for cell proliferation in both normal and cancer epithelial cells.
21 citations
,
March 2019 in “Critical Reviews in Clinical Laboratory Sciences” This review discusses the role of the androgen receptor in breast cancer diagnosis and treatment, and notes a lack of new research results on its therapeutic potential.
20 citations
,
February 2016 in “American Journal of Pathology” This study indicates that the OVOL1-OVOL2 axis may play a significant role in hair follicle differentiation and growth, potentially serving as therapeutic targets for hair disorders like alopecia and in the tumorigenesis of pilomatricoma.
14 citations
,
January 2018 in “Scientific reports” This study demonstrated that bioluminescence imaging of NG2+ cells in transgenic rats allows in vivo monitoring of hair follicle cycles to study hair growth and follicle regeneration.
11 citations
,
January 2013 in “Methods in molecular biology” This study describes a method for labeling and tracking hair follicle stem cells in mouse skin using a Cre/lox recombination system with tamoxifen, providing insights into stem cell behavior and contribution to tissue regeneration.
10 citations
,
May 2019 in “BMC Complementary and Alternative Medicine” This study found that Bacillus/Trapa japonica fruit ferment filtrate extracts enhanced human hair follicle dermal papilla cell proliferation through the Akt/ERK/GSK-3β signaling pathway, suggesting potential benefits for alopecia treatment.
9 citations
,
May 2023 in “Stem Cell Research & Therapy” This study found that mesenchymal stem cell treatment alleviated atopic dermatitis-like symptoms in a mouse model by modulating immune and inflammatory responses, with gene expression changes suggesting pathways for potential personalized treatment approaches.
4 citations
,
August 2022 in “International Journal of Molecular Sciences” This study found that cultured foreskin is not suitable for studying H2A.J-related tissue changes during radiation-induced dermatitis due to existing high H2A.J expression and cytokine secretion even without irradiation.