56 citations
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January 2004 in “Dermatology” This study found that 87% of patients with stage IIA and IIB melanoma treated with low-dose alpha-interferon reported cutaneous side effects, with the most common being hair loss.
30 citations
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December 1999 in “International Journal of Dermatology” In this uncontrolled study, ivermectin treatment for scabies resulted in the resolution of symptoms and negative skin scrapings in most patients at follow-ups.
13 citations
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July 2019 in “Toxicology research” In this study, ethanamizuril was found to cause alopecia, biochemical changes, and organ damage at higher doses in rats, with a no-observed-adverse-effect level of 20 mg/kg over 30 days.
41 citations
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December 2008 in “Journal of the American Academy of Dermatology” This review discusses fixed drug eruption (FDE) potentially linked to finasteride and emphasizes dermatologists' need to recognize its possible occurrence due to the drug's widespread use, but reports no new clinical results.
54 citations
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September 2012 in “Acta ophthalmologica” This review highlights that various targeted cancer therapies are associated with specific ocular side-effects, emphasizing the importance of awareness among ophthalmologists for timely diagnosis and management.
This study found that Anovlar effectively reduced pain in severe dysmenorrhea cases and regulated cycles in oligomenorrhea patients, but some side effects and occasional treatment failures were reported.
September 2025 in “Experimental & Molecular Medicine” This study observed that the small molecules KY19382 and KY19334 inhibited cancerous traits in human cutaneous squamous cell carcinoma cells by suppressing the Wnt/β-catenin pathway, indicating their potential as treatments for cancers involving CDK1 overexpression and diseases related to CXXC5 accumulation.
In this study, botulinum toxin type A injections reduced the severity of treatment-resistant scalp psoriasis in more patients compared to placebo over a 12-week period.
July 2024 in “Journal of Investigative Dermatology” Brepocitinib reduces interferon signaling in hidradenitis suppurativa patients.
4 citations
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August 2002 in “British Journal of Ophthalmology” This study suggests that intralesional cidofovir might be a treatment option for SCC, as it showed a successful outcome without systemic toxicity in the reported case.
This article reviews the cutaneous side effects of immune checkpoint inhibitors and targeted therapies for skin cancers, noting that while generally mild, these effects can influence treatment decisions and quality of life, underscoring the need for physicians to be aware of these adverse reactions.
58 citations
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February 2016 in “Scientific reports” This study found that dual inhibition of BACE1 and BACE2 in mice affects melanosome maturation and causes dose-dependent hair depigmentation without altering retinal morphology.
January 2026 in “Journal of Applied Pharmaceutical Science” This study identified that the ethanol extract of Selaginella doederleinii may enhance the effectiveness of doxorubicin in treating cervical cancer cells while also providing chemopreventive benefits.
June 2026 in “Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine)” This study observed that a 24-hour pre-treatment with MitoQ significantly protected H9c2 myoblasts from doxorubicin-induced damage while enhancing doxorubicin's effectiveness in prostate cancer cells, outperforming dexrazoxane's effects without compromising the anti-cancer efficacy.
22 citations
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March 1999 in “International Journal of Clinical Practice” This review discusses the use of topical immunotherapy for severe alopecia areata and resistant viral warts, highlighting diphencyprone's advantages and the need for careful handling to avoid staff sensitisation; it reports no new clinical results.
35 citations
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January 2006 in “Cancer Research” This study found that overexpressing PKCδ in transgenic mice did not reduce squamous cell carcinoma development induced by UV radiation, despite its effectiveness against TPA-promoted cancer in these mice.
5 citations
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June 2019 in “JAAD Case Reports” This article discusses the use of imiquimod as a treatment for actinic keratosis, basal cell carcinoma, and human papillomavirus warts, noting both its therapeutic benefits and common side effects such as local inflammation and flu-like symptoms.
1 citations
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July 2024 in “Journal of Investigative Dermatology” TAK-279 effectively reduces psoriasis symptoms and is safe.
April 2023 in “Journal of Investigative Dermatology” This study found that in biopsied skin samples of alopecia areata, a lower anagen/telogen ratio was associated with increased T cell infiltration, and enhancing the PD-1/PD-L1 axis may inhibit CD8+T cell infiltration and improve the condition.
20 citations
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January 2024 in “Journal of the European Academy of Dermatology and Venereology” This study conducted a meta-analysis and found that among therapies for alopecia areata, baricitinib_4 mg was most likely to be effective, followed by ritlecitinib and ivarmacitinib, while other treatments like dupilumab and secukinumab were less effective.
3 citations
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January 2021 in “Minia Journal of Medical Research” This study observed that a single intraperitoneal injection of cyclophosphamide caused significant destruction of the intestinal mucosa in albino rats.
July 2026 in “American Journal of Clinical Dermatology” In this study, oral JAK inhibitors were found to be significantly more effective than placebo in promoting hair regrowth among adults and adolescents with moderate-to-severe alopecia areata, although they were associated with an increased risk of adverse events.
15 citations
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December 2020 in “Pharmacology Research & Perspectives” This review discusses targeting host cell proteases as a novel approach to inhibit SARS-CoV-2 infection, highlighting transcriptional modulation and enzymatic inhibition as promising therapeutic strategies, but it reports no new clinical findings.
November 2022 in “Journal of Investigative Dermatology” This study found that short-term treatment with ROCKi significantly increased keratinocyte stem cell proliferation without affecting their stemness, suggesting a potential safe approach for improving in vitro keratinocyte cultures for clinical applications.
September 2024 in “Journal of the Pakistan Medical Association” In this experimental study, laser irradiation significantly altered the gene expression of cytokines in cultured human T-cell lymphocytes, suggesting that such laser light may photobiomodulate cytokine production in vitro.
20 citations
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August 2020 in “Stem Cell Research & Therapy” This study found that miR-150 enhances the resolution ability of endothelial progenitor cells in venous thrombosis by promoting cell differentiation and proliferation through specific gene regulation pathways.
This study found that Botox® was most effective at a 25 U/ml concentration, while Dysport® and Neurobloc® were optimal at 100 U/ml for producing anhidrotic areas after injections.
August 2019 in “Journal of The American Academy of Dermatology” This study found that bleach baths using 0.005% hypochlorite directly affected serine protease expression in skin cells and reduced skin pH in patients with atopic dermatitis, suggesting potential therapeutic benefits.
142 citations
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December 1991 in “Antimicrobial Agents and Chemotherapy” This study reported that continuous intravenous dextran sulfate was toxic and ineffective as a treatment for symptomatic HIV infection, as it did not improve surrogate markers and caused significant side effects.
8 citations
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April 2021 in “Journal of Clinical Investigation” Finasteride reduces opioid use and withdrawal symptoms in animals.