Histological Study of the Damaging Effect Induced by Cyclophosphamide on Intestinal Mucosa of Adult Male Albino Rat

    January 2021 in “ Minia Journal of Medical Research ”
    Sara Mohamed Naguib Abdel Hafez, Nashwa Fathy Gamal El‐Tahawy, Rasha Tantawi, Soha Abdel- Wahab
    TLDR Cyclophosphamide severely damages the intestinal lining in rats.
    The study investigated the effects of cyclophosphamide on the intestinal mucosa of adult male albino rats. Twenty-four rats were divided into two groups, with one group receiving a single sublethal dose of cyclophosphamide. After two weeks, significant structural changes were observed in the intestinal mucosa of the treated group, including inflammation, degenerative changes, and apoptosis. The study concluded that a single intraperitoneal injection of cyclophosphamide caused massive destruction in the intestinal mucosa.
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