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research 874 Elevated expression of osteopontin splice variants in nonmelanoma skin cancer compared to normal skin and adult keratinocytes
The researchers reported that in nonmelanoma skin cancers, the expression of osteopontin splice variants is significantly higher compared to normal skin, with OPN-a elevated in basal cell carcinoma more than OPN-c.
research Organoids and organ chips in ophthalmology
This review discusses the role of organoids and organ chips in advancing ophthalmological research and therapeutic evaluation, but it reports no new clinical findings.
research Expression Pattern of Cyclooxygenase-2 in Normal Rat Epidermis and Pilosebaceous Unit during Hair Cycle
This study found that COX-2 expression in normal rat skin is linked to the hair cycle, with varying levels observed in different skin structures during anagen, catagen, and telogen phases.
research Molecular Regulation and Cellular Heterogeneity in Skin Repair and Hair Follicle Regeneration
This dissertation reported that the loss of Ovol2 impairs hair follicle regeneration and wound repair in mice, highlighting its role in regulating directional migration of epithelial cells.
research 486 Molecular Mechanisms of Type II Spiral Ganglion Neuron Development
research Sesn2/AMPK/mTOR signaling mediates balance between survival and apoptosis in sensory hair cells under stress
This study found that the absence of the stress-responsive protein Sesn2 increased hair cell susceptibility to gentamicin in the inner ear, indicating Sesn2's potential protective role against aminoglycoside-induced damage.
research A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis
This study found that overexpression of the enzyme ornithine decarboxylase in transgenic mice led to UVB-induced skin tumors, but this was prevented by the ODC inhibitor α-difluoromethylornithine.
research Characterization of Prostaglandin F2α Receptors in Human Eyelids
This study found that PGF 2α receptors were predominantly present in the inner root sheath of the bulb and stem of human eyelashes during the anagen phase.
research OVS Announces
This research reports that partial orthokeratology combined with daytime spectacle correction effectively slowed myopic progression in high myopes, with a 63% reduction in axial elongation compared to spectacle use alone.
research Intraretinal variation in disease severity in the Oat mouse model of gyrate atrophy
In this study, researchers characterized the retinal structure and function of the Oatrhg mouse model of gyrate atrophy, finding localized atrophy without significant retina-wide functional impact, suggesting the model may be useful for testing new treatments using multimodal retinal imaging.
research The Serine Protease Activity of Corin Is Required for Normal Pigment Type Switching
research A pair of transmembrane receptors essential for the retention and pigmentation of hair
This study in mutant mice found that Bmpr2 and Acvr2a are individually redundant, but together essential for normal hair follicle development, with their reduction causing rapid hair cycling and graying.
research Data_Sheet_1_Disruption of Hars2 in Cochlear Hair Cells Causes Progressive Mitochondrial Dysfunction and Hearing Loss in Mice.docx
This study found that knocking out the Hars2 gene in mouse cochlear hair cells led to mitochondrial dysfunction and ROS stress, resulting in progressive hearing loss and differential effects on inner and outer hair cells.
research Reviewer #2 (Public Review): CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells
CaBP1 and 2 are necessary for maintaining calcium currents and hearing in inner ear cells.
research 1458 EMT-inhibiting transcription factor Ovol2 regulates directional cell migration and proliferation in adult skin epithelia
This study found that the loss of transcription factor Ovol2 in epidermal and hair follicle stem cells leads to migration defects, which are partially improved by deleting the EMT-inducing Zeb1.
research GLI2 Is Expressed in Normal Human Epidermis and BCC and Induces GLI1 Expression by Binding to its Promoter
GLI2 activates GLI1, promoting skin tumor growth and hair development.
research β-Catenin Inactivation Is a Pre-Requisite for Chick Retina Regeneration
This study suggests that inactivation of β-catenin is necessary for chick retina regeneration, as it allows cells to enter the cell cycle during injury and promotes regeneration without needing FGF2.
research Defining compartmentalized stem cell populations with distinct cell division dynamics in the ocular surface epithelium
This study found that the ocular surface epithelium in mice contains distinct stem cell populations with unique cell division dynamics that change behaviorally in response to different levels of injury.
research Osteopontin Gene is Expressed in the Dermal Papilla of Pelage Follicles in a Hair-Cycle-Dependent Manner
This study found that osteopontin mRNA is abundantly expressed in dermal papilla cells during the catagen phase of hair growth in rats, suggesting a role in this phase.
research 1298 External light activates hair follicle stem cells through eyes via the ipRGC-SCN-sympathetic neural circuit
This study found that external light can rapidly activate hair follicle stem cells in animals via a retinal light-sensing pathway linked to the central and autonomic nervous systems.
research SOX2 in the Skin
This review discusses the role of Sox2 in skin development, hair follicle regeneration, cancer, and wound healing, and reports no new experimental results.
research Clinical Case Notes. Optical coherence tomography of adult-onset foveomacular vitelliform dystrophy
This study presents two cases correlating the clinical appearance of adult-onset foveomacular vitelliform dystrophy with optical coherence tomography findings, describing the location of the yellow vitelliform material.
research Reviewer #1 (Public Review): CaBP1 and 2 enable sustained CaV1.3 calcium currents and synaptic transmission in inner hair cells
CaBP1 and CaBP2 are important for maintaining hearing by supporting continuous calcium currents and nerve signaling in the ear.
research Author Response: Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2
This study found that the transcription factor Meis2 regulates the maturation and innervation of sensory neurons in mice, affecting their response to light touch.
research The co-expression pattern of VEGFR-2 with indicators related to proliferation, apoptosis, and differentiation of anagen hair follicles
This study found that VEGFR-2 activation may play a role in hair follicle differentiation, proliferation, and apoptosis by co-expressing with several key proteins in normal human scalp skin.
research Ornithine Decarboxylase Expression Leads to Translocation and Activation of Protein Kinase CK2 in Vivo
This study suggests that polyamines regulate CK2 enzyme activity and its subcellular distribution, as demonstrated in mouse models and cell cultures with elevated levels of ornithine decarboxylase.
research Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle
This study observed that retinoic acid biosynthesis and signaling in hair follicles have a spatial and temporal regulation linked to distinct stages of the hair cycle in mice.
research Segregation of Incomplete Achromatopsia and Alopecia Due to PDE6H and LPAR6 Variants in a Consanguineous Family from Pakistan
This study identified specific genetic variants as the cause of visual impairment and non-syndromic alopecia in two brothers, reinforcing the link between PDE6H variants and achromatopsia and LPAR6 variants and alopecia.
research Mapping the expression of epithelial hair follicle stem cell‐related transcription factors LHX2 and SOX9 in the human hair follicle
In this study, LHX2 and SOX9 were found to mark distinct epithelial progenitor cell populations within human hair follicles, suggesting roles in maintaining the hair follicle epithelium.