Organoids and Organ Chips in Ophthalmology

    November 2020 in “ The Ocular Surface
    Navid Manafi, Fereshteh Shokri, Kevin Achberger, Masatoshi Hirayama, Melika Haji Mohammadi, Farsad Noorizadeh, Jiaxu Hong, Stefan Liebau, Takashi Tsuji, Peter M. J. Quinn, Alireza Mashaghi
    TLDR Organoids and organ chips can improve eye disease research and treatment.
    The document discussed the development and potential of organoids and organ chips in ophthalmology. These technologies, derived from stem cells, were capable of mimicking eye tissues such as the retina, cornea, and lens, offering a more accurate simulation of human eye structures compared to animal models. They were expected to enhance understanding of eye physiology, uncover unknown aspects of eye disease pathogenesis, and serve as effective tools for evaluating ocular treatments. The increasing burden of eye diseases necessitated a shift towards these innovative technologies, which could provide sensitive, quantitative, and scalable assays for research and therapeutic development.
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