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The reviewers found the manuscript on inflammation's role in cancer stem cells to be relevant but suggested it needs clarity, more background information, discussion on immune cells' role in tumors, updated references, and grammar corrections.

The reviewers suggest clarifying the abstract, adding background on inflammation's effect on stem cells and cancer, discussing immune cells' role in tumors, and considering inflammation's potential to reduce cancer growth.

The reviewers suggest clarifying and expanding on the role of inflammation in stem cell-related cancer development.

The reviewers suggest major revisions for clarity and inclusion of recent findings on inflammation's role in cancer.

Reviewers suggest clarifying the abstract, adding background on inflammation's effect on cancer, discussing immune cell roles, including counter studies, and correcting grammar.

The revised study on how inflammation affects cancer stem cells was accepted after improving clarity and structure.

The revised manuscript on how inflammation affects cancer stem cells was accepted after addressing issues with clarity and detail.

Blocking both main energy pathways can stop hair follicle stem cell-induced skin cancer growth.

Molecular diagnostics help identify genetic defects causing endocrine diseases, improving diagnosis and treatment options.

UV radiation causes skin cancer, but sunscreens and certain drugs can help prevent it.

Chemotherapy and radiotherapy can cause skin side effects like rashes, hair loss, and nail changes, which are usually managed with conservative treatments.

The document concludes that ERBB2 mutations are common in extramammary Paget disease and may respond to systemic treatments like cancer immunotherapy.

Intralesional chemotherapy with 5-fluorouracil and methotrexate may worsen keratoacanthoma-type skin cancer in transplant patients.

WNT10A mutations often cause ectodermal dysplasias, with males showing more tooth issues than females.

FGF5 gene mutations cause long hair in domestic cats.

The document concludes that while some organisms can regenerate body parts, mammals generally cannot, and cancer progression is complex, involving mutations rather than a strict stem cell hierarchy.

Mutations in Gasdermin A3 cause skin inflammation and hair loss by disrupting mitochondria.

Stem cells compete for space using cell adhesion, and mutations can affect their competitive success, with implications for tissue health and disease.

Mutations in Plcd1 and Plcd3 together cause severe hair loss in mice.

Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.

The ITGB6 gene is important for tissue repair and hair growth, and mutations can lead to enamel defects and other health issues.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

The document concludes that Borrelia afzelii causes a skin condition in France, a gene is linked to hair loss in Caucasian women, and various genetic mutations affect skin diseases.

The transgene likely activated an oncogene or interrupted a tumor suppressor gene, causing melanoma in mice.

Keratin mutations cause skin diseases and could lead to new treatments.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

Most adrenal cortex tumors are benign and non-secreting, but proper diagnosis and treatment are important due to the rare possibility of cancer.

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.