February 2024 in “World journal of stem cells” This review highlights the potential of adipose-derived mesenchymal stem cells as a cost-effective solution for tissue restoration and regeneration in ophthalmic and oculoplastic surgeries, addressing unmet needs in reconstructive procedures.
52 citations
,
April 2023 in “The Ocular Surface” June 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study reported that distinct stem/progenitor populations in the ocular surface epithelium have different cell division frequencies and respond differently to injury, with specific spatial compartmentalization and migration behaviors.
15 citations
,
November 2020 in “Development” This study found that the ocular surface epithelium in mice contains distinct stem cell populations with unique cell division dynamics that change behaviorally in response to different levels of injury.
1 citations
,
January 2025 in “Veterinary Medicine International” This review found promising benefits of platelet-rich plasma for treating ocular surface diseases in animals, but methodological flaws currently preclude recommending it as standard care.
27 citations
,
May 2011 in “Current Opinion in Ophthalmology” This study reports that a new transplantation technique using tissue-engineered stem cells successfully reconstructed corneal epithelium in an animal model of severe ocular surface disease.
94 citations
,
January 2007 in “Cutaneous and Ocular Toxicology” This review discusses the long-term cutaneous and ocular complications from sulfur mustard exposure in the Iranian population, identifying pruritus and malignant changes as significant issues and highlighting eye surface damage leading to visual decline.
35 citations
,
April 2006 in “Ocular Surface” This review discusses adverse effects of cosmetic products and procedures on the ocular surface, including mild discomfort to severe vision-threatening conditions, and reports no new clinical results.
11 citations
,
June 2024 in “Clinical ophthalmology” This study highlights that Demodex mites, commonly found on human skin, can cause significant eye and skin issues such as blepharitis, rosacea, and dermatitis when present in abnormally high densities, underscoring the need for targeted management strategies.
June 2022 in “Indian journal of clinical and experimental opthalmology” This case report details the ocular complications of Hutchinson-Gilford Progeria syndrome in a 20-year-old Bangladeshi patient, highlighting symptoms like dry eyes, Meibomian gland dysfunction, and cataracts.
135 citations
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October 2010 in “Stem Cells” This study found that stem cells from mouse hair follicles successfully reconstructed the ocular surface in most limbal stem cell deficiency mice, demonstrating potential for treating the condition in a mouse model.
15 citations
,
June 2021 in “Medicina” This study found that combined intense pulsed light and low-level light therapy significantly improved ocular surface outcomes and quality of life for patients with meibomian gland dysfunction and dry eye disease.
9 citations
,
November 2024 in “Biotechnology for Sustainable Materials” This paper critically reviews recent advances in the use of keratin-based biomaterials, highlighting their potential applications in wound healing, drug delivery, and tissue regeneration due to their biocompatibility, biodegradability, and ability to support cell growth.
1 citations
,
September 2019 in “Journal of surgery and medicine” This study found that women with polycystic ovary syndrome had worse meibomian gland morphology and ocular surface conditions compared to healthy controls, as observed through non-contact meibography.
1 citations
,
October 2025 in “Transfusion Medicine and Hemotherapy” This review synthesizes current evidence on platelet-rich plasma for dry eye disease and reports no new results; the authors emphasize the need for standardized trials to validate these approaches.
1 citations
,
January 2011 in “International Journal of Trichology” Hair follicle stem cells have significant potential for treating various disorders.
January 2025 in “Clinical and Experimental Optometry” This study found that men with androgenetic alopecia had significantly higher rates of dry eye symptoms and meibomian gland dysfunction compared to healthy controls, suggesting a potential link between the condition and these ocular issues.
May 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, primary cilia were found to contribute to meibomian gland enlargement and lipid production, though they are not necessary for normal gland development.
December 2011 in “Ophthalmology” This article discusses the potential association between Demodex and blepharitis but reports no new findings, as the authors evaluated systemic associations without data on Demodex infestation.
33 citations
,
October 2017 in “Drug Safety” SJS/TEN survivors often have severe, overlooked long-term physical problems that are not properly treated after leaving the hospital.
32 citations
,
January 2016 in “Development” This study introduced Scd3-Cre mice, which enabled sebocyte-specific manipulation, revealing that sebaceous lipid depletion impaired water repulsion, thermoregulation, and the ocular surface, resembling Meibomian gland dysfunction.
30 citations
,
June 2013 in “Optometry and vision science” This study reports that a clinical sequence can help eye care practitioners identify Demodex mites, which are often underdiagnosed and undertreated in ocular surface diseases.
2 citations
,
September 2023 in “Curēus” This study reported that topical spironolactone improved lid margin vascularity, corneal fluorescein staining, and disease severity scores in patients with ocular graft-versus-host disease, suggesting a potential therapeutic role by enhancing corneal lipid production with minimal adverse effects.
January 2025 in “Turkiye Klinikleri Journal of Ophthalmology” This study found no significant differences in dry eye disease parameters between female patients with androgenetic alopecia and healthy controls, although meibum quality was better in the alopecia group, suggesting complex hormonal interplay affecting ocular health.
20 citations
,
October 2023 in “Small” This study discusses the expanding use of microneedles beyond transdermal drug delivery, highlighting recent advancements for treating hair loss, eye diseases, and oral disorders, while emphasizing future challenges in generalizing this technology.
11 citations
,
June 2025 in “Polymers” This review reports on recent surfactant-based niosome formulations, including those with polysaccharides, for versatile drug delivery applications such as ocular, oral, and transdermal settings, while discussing their limitations and potential prospects.
256 citations
,
October 2013 in “Nature Communications” This study demonstrates that bioengineered lacrimal gland germs can successfully develop and restore tear production and ocular surface protection in a mouse model with lacrimal gland dysfunction.
162 citations
,
December 2008 in “Stem Cells” This study found that murine vibrissa hair follicle stem cells can be differentiated into corneal epithelial-like cells in vitro using limbus-specific microenvironmental factors, suggesting a potential therapeutic source for ocular surface disorders.
December 2012 in “Canadian journal of ophthalmology” This case report describes a rare complication of eyelash transplantation, where it resulted in trichiasis and corneal surface damage, highlighting the need for preoperative counseling about potential ocular risks.
25 citations
,
August 2020 in “Experimental eye research/Experimental Eye Research” This review discusses cornea-specific keratin expression patterns in human and mouse development and reports no new experimental results; it highlights the need for investigating keratin mutations' role in pathology.