Ocular Manifestations of Hutchinson-Gilford Progeria Syndrome: A Rare Presentation
June 2022
in “
Indian journal of clinical and experimental opthalmology
”
Hutchinson-Gilford Progeria Syndrome madarosis lagophthalmos dry eye keratinized ocular surface Meibomian gland dysfunction vascularized cornea symblepharon corneal opacification cataract hair loss scleroderma HGP eyebrow loss incomplete eyelid closure dry eyes keratinized eye surface Meibomian gland issues vascularized eye eyelid adhesion corneal clouding cataracts baldness skin hardening
TLDR The report shows a young man with Hutchinson-Gilford Progeria Syndrome had typical and additional eye problems related to the disease.
This case report details the ocular symptoms of a 20-year-old Bangladeshi male with Hutchinson-Gilford Progeria Syndrome (HGP), a rare genetic disorder causing accelerated aging. The patient exhibited typical eye-related features of HGP, including prominent eyes, loss of eyebrows (madarosis), and incomplete eyelid closure (lagophthalmos). Additional ocular issues noted were dry eye, a keratinized ocular surface, dysfunction of the Meibomian glands, a vascularized cornea, symblepharon (partial adhesion of the eyelid to the eyeball), corneal opacification, and cataract formation. Systemic manifestations included aged facial appearance, visible scalp veins, widespread hair loss with a "plucked bird" look, and skin changes resembling scleroderma.
