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This article is a reference guide for various dermatological terms, treatments, and conditions, and reports no new clinical findings.
research 63418 JAK3/TEC kinase pathways are active in alopecia areata lesions, and their inhibition with Ritlecitinib prevents αCD3/αCD28+IL-2 induced immune privilege collapse in healthy hair follicles ex vivo
Ritlecitinib may help treat alopecia areata by protecting hair follicles.
research Normalized androgen ratio: its application to clinical dermatology
This study found that the normalized androgen ratio (NAR) could help evaluate androgen activity in women with acne vulgaris, hirsutism, and androgenetic alopecia, showing elevated NAR in some patients.
research Formulation of Hair Tonic of Meniran (Phyllanthus niruri L.) Ethanol Extract as Hair Grower in Male White Rat (Rattus norvegicus) Wistar Strain
In this study, topical application of tonic preparations containing 5% ethanol extract of Phyllanthus niruri to shaved mice showed potential as a hair growth enhancer, as indicated by observations of increased hair length and weight over a 21-day period.
research Formulasi Sediaan Losio Ekstrak Etanol Meniran (Phyllanthus niruri L.) Sebagai Penumbuh Rambut Terhadap Tikus Putih (Rattus norvegicus) Jantan Galur Wistar
This study found that lotion containing ethanolic extract of Phyllanthus niruri and 1% menthol enhanced hair growth in white Wistar rats more than a formula without menthol, although not significantly.
research Efficacy and safety evaluations of topical proretinal nanoparticles
This study found that proretinal nanoparticles, applied topically, are safe and effective for penetration into hair follicles, enhancing retinoid biological activity in the skin while reducing irritation compared to conventional retinal formulations.
research Keratin nanoparticle-loaded hydrogel microneedles for programmed repair of radiation-induced skin injury
This study concluded that the KNPs@M/G microneedle system offers a promising strategy for treating radiation-induced skin injury by promoting antioxidative, anti-inflammatory, and regenerative effects.
research Efficacy and Safety of Ritlecitinib in the Asian Subpopulation of the ALLEGRO ‐2b/3 and ALLEGRO ‐ LT Clinical Studies for Alopecia Areata
This study reports that ritlecitinib 50 mg, with or without an initial loading dose, demonstrated meaningful and sustained efficacy up to 24 months in the Asian subpopulation with severe alopecia areata, showing significant scalp, eyebrow, and eyelash hair regrowth, along with an acceptable safety profile.
research リリース:Microsoft RSAT for Windows 7 SP1(20110412-1)
This report describes a case of trachyonychia with associated various types of lichen planus in a young male, highlighting the importance of accurate diagnosis for effective treatment.
research Rationale and Design of a Novel, Phase 3, External and Synthetic Placebo-Controlled Clinical Trial of Ritlecitinib 50 mg and 100 mg for Alopecia Areata
This study evaluates the efficacy and safety of a higher dose (100-mg) of ritlecitinib for treating severe alopecia areata, comparing it to external and synthetic placebo control groups.
research Phytosome Based Drug Delivery of Naringenin and Naringin: Development, Characterization, and In Vivo Evaluation
This study reported that phytosome formulations of citrus flavonoids naringenin and naringin showed significantly increased oral bioavailability and plasma drug concentration in rabbits, suggesting that phytosome technology effectively addresses the pharmacokinetic limitations of these compounds.
research Efficacy and Potential Mechanisms of Naringin in Atopic Dermatitis
In this study, topical naringin was found to significantly improve dermatitis severity and reduce inflammatory markers in a mouse model of atopic dermatitis, suggesting its potential as a therapeutic agent for this condition.
research Efficacy and safety of ritlecitinib in Asian patients with alopecia areata: A subgroup analysis of the ALLEGRO phase 2b/3 trial
This study found that in Asian patients aged 12 and older with alopecia areata and significant hair loss, ritlecitinib showed clinical efficacy in improving hair regrowth and eyebrow and eyelash scores over 48 weeks, with an acceptable safety profile observed throughout.
research 778 Designing and utilizing a c-Rel specific bioassay in drug repurposing screen for HNSCC
A new test helps find drugs to treat head and neck cancer by targeting c-Rel.
research Evaluation of hair growth promoting activity of Phyllanthus niruri.
In this study, petroleum ether extracts of Phyllanthus niruri promoted hair regrowth in testosterone-induced alopecia in rats by inhibiting the 5α-reductase enzyme.
research LEKTI: Netherton Syndrome and Atopic Dermatitis
This article discusses research about Netherton syndrome, highlighting its contributions to understanding epidermal structure, immune responses, and processes like atopic dermatitis, but it reports no new clinical findings.
research Patents and Licenses
This chapter discusses the process from ideation to patent and licensure for biotechnologies, offering an introduction to the intersection of business, law, and biotechnology without reporting new results.
research First drug for severe alopecia recommended by NICE could benefit 14,000 patients
In this report, NICE has approved ritlecitinib, an oral kinase inhibitor, as the first recommended treatment for severe alopecia areata in individuals aged 12 and older.
research Pharmacologic Management of Acute Attacks of Migraine and Prevention of Migraine Headache
This guideline discusses evidence-based recommendations for managing acute migraine attacks and preventing migraines, highlighting effective treatments such as NSAIDs and triptans but reports no new clinical findings.
research Interventions for central serous chorioretinopathy: a network meta-analysis
This review observed limited evidence of clinically significant benefits from treatments for acute central serous chorioretinopathy, which often resolves spontaneously, but identified PDT and micropulse laser as the most promising for further trials.
research Connecting corporations and communities: Towards a theory of social inclusive open innovation
This paper describes how market and social forces impact the development of social innovations, offering ways to bridge social gaps by engaging youth and connecting corporations with communities.
research Efficacy of Carbazole Alkaloids, Essential Oil and Extract of Murraya koenigii in Enhancing Subcutaneous Wound Healing in Rats
This study found that mahanimbicine and a crude extract of Murraya koenigii may enhance wound healing in rats by promoting faster wound contraction and higher collagen deposition.
research Inhibition of 5α-reductase in the nucleus accumbens counters sensorimotor gating deficits induced by dopaminergic activation
Finasteride may help improve certain brain function issues linked to dopamine.
research Isolation rearing-induced reduction of brain 5α-reductase expression: Relevance to dopaminergic impairments
Isolation stress in rats reduces brain enzyme levels, affecting dopamine function.
research Mechanical Fractionation of Adipose Tissue—A Scoping Review of Procedures to Obtain Stromal Vascular Fraction
This study reviewed the efficacy of mechanical fractionation techniques to produce tissue stromal vascular fraction (tSVF) and found that tSVF injections are particularly effective for conditions like osteoarthritis and wound healing, with centrifugation before fractionation improving isolation efficiency regardless of preparation method.
research The Influence of Age-Related Cues on Health and Longevity
This study found that age-related cues, such as perceived appearance, clothing, and family structure, may influence health outcomes and longevity in different ways.
research Ethosome: a novel vesicular carrier for transdermal drug delivery
This article reviewed the preparation, application, and characterization of ethosomes as drug delivery transporters and reported that in a double-blind randomized clinical study, ethosomal acyclovir significantly improved all evaluated parameters in skin delivery, highlighting potential for novel therapies.
research Role of Polyphenols in Dermatological Diseases: Exploring Pharmacotherapeutic Mechanisms and Clinical Implications
This source reviews the potential of polyphenols as therapeutic and preventive treatments for common skin disorders such as acne, fungal infections, dermatitis, alopecia, and skin cancer, emphasizing their anti-inflammatory and antimicrobial effects and ability to penetrate the skin barrier.
research The Role of the Gut Microbiome and Microbial Dysbiosis in Common Skin Diseases
This review explores the connection between the gut-skin axis and the development of dermatological conditions like atopic dermatitis, psoriasis, alopecia areata, and acne, and discusses the potential of probiotics in reshaping the microbiome to alleviate these skin issues.