Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that in mouse pancreatic β-cells, the disruption of keratin filaments due to a specific mutation in keratin 18 resulted in altered GLUT2 localization, with less GLUT2 present on the plasma membrane compared to cells with normal keratin.

This study suggests that chronic treatment with TPA in mouse skin selectively expands a keratinocyte subpopulation hyperinducible for ODC, which may be a key target for neoplastic transformation.

This study found that endothelial cells under serum deprivation significantly upregulated genes related to inflammation and coagulation, which may impact outcomes in tissue transfer procedures.

In this review, the researchers detailed how the p63 transcription factor influences epithelial stem cell activities such as self-renewal, differentiation, and proliferation, highlighting the role of TAp63 and ΔNp63 isoforms in both normal tissue development and cancer pathogenesis.

This study reported that high ornithine decarboxylase expression and decreased keratin K1 and K10 expression may serve as useful markers for early stages of tumor development in mouse skin.

The AUTS2 gene is linked to neurological disorders and may affect human brain development and cognition.

This study found that a multicolor panel of four surface markers can identify new stem cell populations in mouse hair follicles, providing insights into stem cell diversity and gene expression discrepancies during tissue culture.

This study found that the sheep high-sulfur keratin promoter B2C initiated GFP expression in sheep fibroblasts but remained inactive in mouse embryos.

This study found that the mitotic arrest deficient protein MAD2B negatively affects TCF4-induced growth and proliferation of dermal papilla cells, which are vital for hair follicle development.

This study found that loss of the Ptch2 receptor in mice leads to increased incisor growth and enhanced mesenchymal stem cell differentiation, highlighting Ptch2's role in organ regenerative potential.

This study suggests that Keratin 15 expression in stratified epithelia may be regulated by two distinct mechanisms involving PKC/AP-1 pathway for differentiation and FOXM1 for basal cells, challenging its reliability as a sole stem cell marker.

This study reports that the recombinant expression vector pcDNA3.1-KK demonstrates specific expression in the skin of newborn mice.

In this study, researchers found that the FOS gene may play a significant role in promoting hair follicle development in Tan sheep between birth and the Er-mao period.

In this study, researchers identified that keloid fibroblasts respond to neurotransmitters from catecholaminergic nerves by producing bone matrix proteins, mediated by β1-adrenergic receptor activation, leading to fibro-osseous reprogramming; blocking this signaling in a rodent model prevented the development of keloid-like pathology.

This study found that hypertrophic chondrocytes at the fracture callus border may convert to osteoblasts, influenced by vasculature and pluripotency gene expression.

In this study, researchers found that the cornification process in the nuptial pads of Xenopus frogs involves the expression of the type II hair keratin homolog, krt59, and is regulated by the transcription factor hoxc13, showing similarities to mammalian hair evolution.

This study observed that nestin-positive, K15-negative cells in hair follicles may play a crucial role in hair follicle regeneration in patients with alopecia areata.

This study suggests that the NGF/TrkA/CREB system plays a crucial role in promoting outer root sheath cell proliferation in cashmere goats, which may aid in marker-assisted breeding.

The study demonstrated that both DKK2 and SOSTDC1 are necessary for normal timing of the first catagen phase in mice hair growth cycles.

This study found that systemic treatment with DS77754007, a KLK5 inhibitor, improved skin symptoms in a mouse model of Netherton Syndrome more effectively than certain antibody treatments, suggesting KLK5 inhibition as a promising therapeutic approach for this condition.

This study reports that hair follicle stem cells, termed HAP stem cells, can differentiate into neuronal and glial cells, enhancing nerve repair and locomotor recovery after injury.

This study found that antroquinonol inhibited CD8+ T cell proliferation and reduced proinflammatory cytokine secretion in vitro, while also ameliorating H2O2-induced depigmentation and resisting reductions in hair follicle length, skin thickness, and tyrosinase expression in mice.

This study developed rat monoclonal antibodies that specifically detect Pax1/PAX1 protein, which could improve diagnostic protocols for conditions involving deregulated Pax1/PAX1 expression.

This study identified two novel genes, pmg-1 and pmg-2, expressed in various skin and gland tissues and potentially involved in the differentiation of epithelial cells in epidermal appendages.

This research found that human adipose stem cells maintained their immaturity and potential to differentiate into beige adipocytes in an endothelial growth medium, correlating with increased SOX2 expression linked to beige and brown adipocyte activation.

This study reports that lower levels of N-myc mRNA are observed when hair growth ceases in certain phases in mice, and attempts to create transgenic mice for further investigation resulted in high embryonic mortality.

This study suggests that glycoproteins tenascin-C and tenascin-W may influence the migration and proliferation of CD34-positive stem cells in mouse whisker follicles.