January 2019 in “Current research in diabetes & obesity journal” A woman with type 2 diabetes developed alopecia areata, suggesting a link between the two autoimmune conditions.
This study found that abnormal carbohydrate metabolism linked to increased serum fasting insulin levels is associated with 20% of women with polycystic ovary syndrome, and these women exhibit more symptoms compared to those with normal insulin levels.
40 citations
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April 2008 in “European journal of endocrinology” In this study, treatment with insulin sensitizers significantly increased adipose tissue GLUT4 mRNA expression and improved insulin resistance, menstrual patterns, and androgen profiles in PCOS patients, with rosiglitazone being more effective than metformin.
May 2025 in “Research Journal of Biotechnology” This study found that diabetic individuals experienced significant changes in hair characteristics, including reduced thickness, strength, and altered growth cycle phases, correlated with poor glycaemic control and haematological variations compared to healthy controls.
1 citations
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July 2024 in “Human Reproduction” This study found that for obese patients undergoing sleeve gastrectomy, concurrent type 2 diabetes is linked to worsened metabolic but milder reproductive aspects of PCOS and does not hinder the return to regular menstruation one year after surgery.
4 citations
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August 2025 in “Scientific Reports” This study found that hair analysis is an effective non-invasive method for assessing metabolic fluctuations, showing stable advanced glycation end products levels that correlate with age and differ significantly between diabetic and non-diabetic rats.
4 citations
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December 1962 in “European journal of endocrinology” Alloxan diabetes, methylthiouracil, cortisone, and adrenaline affect how white mice hair follicles use glucose and cystine and their cell division.
August 2013 in “Fertility and sterility” This study suggests that metformin might serve as a diagnostic and therapeutic option to distinguish insulin resistance-related ovarian testosterone excess from a testosterone-secreting tumor in women with virilization.
23 citations
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June 2016 in “Journal of Veterinary Internal Medicine” This case series reports three cats diagnosed with hypersomatotropism due to GH-secreting pituitary adenomas without concurrent diabetes mellitus, highlighting the potential for underdiagnosis in non-diabetic cats.
May 2022 in “The Journal of Clinical Pharmacology” This study suggests that metformin has a stronger impact on gonadotroph hormone levels in men with early-onset androgenic alopecia compared to those with normal hair growth.
August 2026 in “The Laryngoscope” This study found that adults with type 2 diabetes or obesity using semaglutide and tirzepatide experienced higher odds of nonscarring alopecia, such as telogen effluvium, compared to those using other GLP-1 receptor agonists, with hair loss potentially linked to physiologic stress from weight loss.
July 2026 in “Materials Today Bio” This study developed a novel hydrogel that improved healing in diabetic infected wounds on mobile sites by controlling infection, inflammation, and mechanical stress, promoting skin regeneration without excess scarring.
February 2010 in “Journal of The American Academy of Dermatology” This study found that nonobese women with idiopathic hirsutism had higher fibrinogen levels and lower nitrite/nitrate concentrations compared to controls, similar to those with PCOS.
1 citations
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December 2024 in “Journal of Clinical Medicine” This study found that in overweight or obese women with PCOS and insulin resistance, those with lower baseline prolactin levels exhibited a greater decrease in insulin resistance after 6-8 months of metformin treatment, compared to those with higher prolactin levels.
1 citations
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May 1992 in “Pharmacological Research”
October 2004 in “Australian Prescriber” This review discusses the lack of long-term clinical studies on metformin's cardiovascular benefits in women with polycystic ovary syndrome, highlighting lifestyle changes as a crucial management strategy for reducing associated risks.
October 2023 in “Benha Journal of Applied Sciences” In this study, patients with androgenic alopecia were found to have higher levels of insulin, glucose, and HOMA-IR compared to healthy individuals, suggesting distinct metabolic profiles that may contribute to the condition's development.
96 citations
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February 2007 in “The Journal of Clinical Endocrinology & Metabolism” This review discusses the high prevalence of androgen excess and PCOS in women with type 1 diabetes but reports no new clinical findings; the authors highlight the underdiagnosis of hyperandrogenism in these patients.
April 2018 in “The Journal of Urology” In this study, men with pre-diabetes seeking treatment for erectile dysfunction had worse hormonal and metabolic profiles and a higher risk of severe erectile dysfunction compared to those without pre-diabetes.
1 citations
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January 1996 in “Gynecological endocrinology” This article describes a case of severe hyperandrogenism in a 35-year-old woman where high-resolution imaging ruled out tumors, and treatment with cyproterone acetate normalized testosterone levels.
2 citations
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March 1976 in “PubMed” In this study, Neogynon was found to be 100% effective as a contraceptive, with no observed failures in 3129 cycles among 184 women, while side effects included changes in endometrial patterns and some central nervous system effects.
8 citations
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April 2019 in “Journal of the Endocrine Society” In this study, long-term normalization of testosterone levels in postmenopausal women with hyperandrogenism did not improve body mass index, glucose, or lipid metabolism.
60 citations
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February 2010 in “Gynecological Endocrinology” This study suggests that adding metformin to diet and exercise improves insulin resistance and hyperandrogenism in women with PCOS, though lifestyle changes alone may enhance menstrual cycles.
5 citations
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June 2018 in “Journal of Diabetes, Metabolic Disorders & Control” This study found that women with polycystic ovary syndrome have higher triglyceride and fasting glucose levels in obese individuals and higher total cholesterol levels in non-obese individuals compared to healthy women.
October 2022 in “Amplla Editora eBooks” Gestational diabetes increases risks for mothers and babies, needing early diagnosis and care.
11 citations
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December 2017 in “Diabetes Therapy” This study highlights the need to prioritize early prevention of type 2 diabetes mellitus by focusing on early pathophysiologic mechanisms such as insulin resistance, rather than hyperglycemia, as conditions like non-alcoholic fatty liver disease and polycystic ovarian syndrome are early indicators of future diabetes risk.
4 citations
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December 2021 in “Pharmacological Reports” This study found that metformin's metabolic benefits, such as reducing fat content and improving insulin sensitivity, were less pronounced in men with early-onset androgenic alopecia compared to those with normal hair growth, possibly due to differences in systemic inflammation and vitamin D status.
July 2026 in “Journal of the American Academy of Dermatology” GLP-1 and GLP-1/GIP agonists may increase the risk of hair loss.
5 citations
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August 2024 in “Cureus” In this study, GLP-1 receptor agonists reduced BMI and improved metabolic and reproductive outcomes in women with PCOS, though the long-term effects remain unclear.
February 2025 in “medRxiv (Cold Spring Harbor Laboratory)” This study observed an increased risk of alopecia areata among new users of GLP-1 agonists semaglutide and liraglutide compared to users of bupropion-naltrexone, highlighting potential hair loss concerns with these medications.