The Impact of Type 2 Diabetes on Polycystic Ovary Syndrome in Patients Undergoing Sleeve Gastrectomy

July 2024 in “ Human Reproduction ”

Tao Zhu, Yian Zhao, Xiaocheng Bi, Peikai Zhao, Teng Liu, Yuxuan Li, Shumin Li, Shigang Zhao, Shaozhuang Liu, Xin Huang

TLDR Women with both type 2 diabetes and PCOS have worse metabolic issues but milder reproductive symptoms after sleeve gastrectomy.

This study investigated the impact of type 2 diabetes mellitus (T2DM) on polycystic ovary syndrome (PCOS) in 329 women undergoing sleeve gastrectomy (SG) for obesity. It found that patients with both PCOS and T2DM (n=98) experienced more severe metabolic issues, such as insulin resistance and dyslipidemia, compared to those with only PCOS (n=149). However, the reproductive features were milder in the PCOS+T2DM group, with lower testosterone levels and fewer cases of polycystic ovarian morphology. Despite taking longer to resume regular menstruation post-surgery, both groups had similar rates of regular menstruation (85% vs. 87%) one year after SG. The study highlights the need for further research on the comprehensive impact of T2DM on PCOS prognosis after SG.

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